The role of stem cell transplantation for chronic myelogenous leukemia in the 21st century

被引：45

作者：

Barrett, A. John ^{[1
]}

Ito, Sawa ^{[1
]}

机构：

[1] NHLBI, Stem Cell Allotransplantat Sect, Hematol Branch, NIH, Bethesda, MD 20892 USA

来源：

BLOOD | 2015年 / 125卷 / 21期

基金：

美国国家卫生研究院;

关键词：

CHRONIC MYELOID-LEUKEMIA; CHRONIC GRANULOCYTIC-LEUKEMIA; BCR-ABL TRANSCRIPTS; DONOR LEUKOCYTE TRANSFUSIONS; BONE-MARROW-TRANSPLANTATION; TOTAL-BODY IRRADIATION; QUALITY-OF-LIFE; IMATINIB MESYLATE; ALLOGENEIC TRANSPLANTATION; TYROSINE KINASE;

D O I：

10.1182/blood-2014-10-567784

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The introduction of tyrosine kinase inhibitors (TKIs), a treatment of chronic myelogenous leukemia (CML), has largely replaced curative strategies based on allogeneic stem cell transplantation (SCT). Nevertheless, SCT still remains an option for accelerated/blastic-phase and selected chronic-phase CML. Transplant outcomes can be optimized by peritransplant TKIs, conditioning regimen, BCR-ABL monitoring, and relapse management. Controversies exist in transplant timing, pediatric CML, alternative donors, and economics. SCT continues to serve as a platform of "operational cure" for CML with TKIs and immunotherapies.

引用

页码：3230 / 3235

页数：6

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