Suboptimal Response to Coronavirus Disease 2019 Messenger RNA Vaccines in Patients With Hematologic Malignancies: A Need for Vigilance in the Postmasking Era

被引：58

作者：

Agha, Mounzer E. ^{[1
]}

Blake, Maggie ^{[1
]}

Chilleo, Charles ^{[3
]}

Wells, Alan ^{[2
]}

Haidar, Ghady ^{[4
]}

机构：

[1] Univ Pittsburgh, Med Ctr, Hillman Canc Ctr, Pittsburgh, PA USA

[2] Univ Pittsburgh, Sch Med, Dept Pathol, Pittsburgh, PA USA

[3] Univ Pittsburgh, Med Ctr, Clin Labs, Pittsburgh, PA USA

[4] Univ Pittsburgh, Div Infect Dis, Sch Med, Pittsburgh, PA USA

来源：

OPEN FORUM INFECTIOUS DISEASES | 2021年 / 8卷 / 07期

基金：

美国国家卫生研究院;

关键词：

antibody; COVID; 19; vaccine; hematological malignancy; SARS; CoV; 2; COVID-19;

D O I：

10.1093/ofid/ofab353

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We measured severe acute respiratory syndrome coronavirus 2 immunoglobulin G responses in 67 patients with hematological malignancies after 2 messenger RNA vaccine doses. Forty-six percent were nonresponders; patients with B-cell chronic lymphocytic leukemia were at highest risk (77% nonresponders). Patients with hematological malignancies should continue wearing masks and socially distancing. Studies of revaccination, boosters, and humoral immune correlates of protection are needed.

引用

页数：5

共 35 条

[11]

Cohen MS, 2021, JAMA-J AM MED ASSOC, V326, P46, DOI [10.1001/jama.2021.8828, 10.1001/jama.2021.88282021.]

[12] Cellular and humoral response after MRNA-1273 SARS-CoV-2 vaccine in kidney transplant recipients [J].

Cucchiari, David ;

Egri, Natalia ;

Bodro, Marta ;

Herrera, Sabina ;

Del Risco-Zevallos, Jimena ;

Casals-Urquiza, Joaquim ;

Cofan, Frederic ;

Moreno, Asuncion ;

Rovira, Jordi ;

Banon-Maneus, Elisenda ;

Ramirez-Bajo, Maria J. ;

Ventura-Aguiar, Pedro ;

Perez-Olmos, Anna ;

Garcia-Pascual, Marta ;

Pascal, Mariona ;

Vilella, Anna ;

Trilla, Antoni ;

Rios, Jose ;

Palou, Eduard ;

Juan, Manel ;

Bayes, Beatriu ;

Diekmann, Fritz .

AMERICAN JOURNAL OF TRANSPLANTATION, 2021, 21 (08) :2727-2739

[13] COVID-19 in Immunocompromised Hosts: What We Know So Far [J].

Fung, Monica ;

Babik, Jennifer M. .

CLINICAL INFECTIOUS DISEASES, 2021, 72 (02) :340-350

[14] Improving the Outcomes of Immunocompromised Patients With Coronavirus Disease 2019 [J].

Haidar, Ghady ;

Mellors, John W. .

CLINICAL INFECTIOUS DISEASES, 2021, 73 (06) :E1397-E1401

[15] Intractable Coronavirus Disease 2019 (COVID-19) and Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Replication in a Chimeric Antigen Receptor-Modified T-Cell Therapy Recipient: A Case Study [J].

Hensley, Matthew K. ;

Bain, William G. ;

Jacobs, Jana ;

Nambulli, Sham ;

Parikh, Urvi ;

Cillo, Anthony ;

Staines, Brittany ;

Heaps, Amy ;

Sobolewski, Michele D. ;

Rennick, Linda J. ;

Macatangay, Bernard J. C. ;

Klamar-Blain, Cynthia ;

Kitsios, Georgios D. ;

Methe, Barbara ;

Somasundaram, Ashwin ;

Bruno, Tullia C. ;

Cardello, Carly ;

Shan, Feng ;

Workman, Creg ;

Ray, Prabir ;

Ray, Anuradha ;

Lee, Janet ;

Sethi, Rahil ;

Schwarzmann, William E. ;

Ladinsky, Mark S. ;

Bjorkman, Pamela J. ;

Vignali, Dario A. ;

Duprex, W. Paul ;

Agha, Mounzer E. ;

Mellors, John W. ;

McCormick, Kevin D. ;

Morris, Alison ;

Haidar, Ghady .

CLINICAL INFECTIOUS DISEASES, 2021, 73 (03) :E815-E821

[16] Efficacy of the BNT162b2 mRNA COVID-19 vaccine in patients with chronic lymphocytic leukemia [J].

Herishanu, Yair ;

Avivi, Irit ;

Aharon, Anat ;

Shefer, Gabi ;

Levi, Shai ;

Bronstein, Yotam ;

Morales, Miguel ;

Ziv, Tomer ;

Arbel, Yamit Shorer ;

Scarfo, Lydia ;

Joffe, Erel ;

Perry, Chava ;

Ghia, Paolo .

BLOOD, 2021, 137 (23) :3165-3173

[17] An mRNA Vaccine against SARS-CoV-2-Preliminary Report [J].

Jackson, L. A. ;

Anderson, E. J. ;

Rouphael, N. G. ;

Roberts, P. C. ;

Makhene, M. ;

Coler, R. N. ;

McCullough, M. P. ;

Chappell, J. D. ;

Denison, M. R. ;

Stevens, L. J. ;

Pruijssers, A. J. ;

McDermott, A. ;

Flach, B. ;

Doria-Rose, N. A. ;

Corbett, K. S. ;

Morabito, K. M. ;

O'Dell, S. ;

Schmidt, S. D. ;

Swanson, P. A. ;

Padilla, M. ;

Mascola, J. R. ;

Neuzil, K. M. ;

Bennett, H. ;

Sun, W. ;

Peters, E. ;

Makowski, M. ;

Albert, J. ;

Cross, K. ;

Buchanan, W. ;

Pikaart-Tautges, R. ;

Ledgerwood, J. E. ;

Graham, B. S. ;

Beigel, J. H. .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (20) :1920-1931

[18] SARS-CoV-2 evolution during treatment of chronic infection [J].

Kemp, Steven A. ;

Collier, Dami A. ;

Datir, Rawlings P. ;

Ferreira, Isabella A. T. M. ;

Gayed, Salma ;

Jahun, Aminu ;

Hosmillo, Myra ;

Rees-Spear, Chloe ;

Mlcochova, Petra ;

Lumb, Ines Ushiro ;

Roberts, David J. ;

Chandra, Anita ;

Temperton, Nigel ;

Sharrocks, Katherine ;

Blane, Elizabeth ;

Modis, Yorgo ;

Leigh, Kendra E. ;

Briggs, John A. G. ;

van Gils, Marit J. ;

Smith, Kenneth G. C. ;

Bradley, John R. ;

Smith, Chris ;

Doffinger, Rainer ;

Ceron-Gutierrez, Lourdes ;

Barcenas-Morales, Gabriela ;

Pollock, David D. ;

Goldstein, Richard A. ;

Smielewska, Anna ;

Skittrall, Jordan P. ;

Gouliouris, Theodore ;

Goodfellow, Ian G. ;

Gkrania-Klotsas, Effrossyni ;

Illingworth, Christopher J. R. ;

McCoy, Laura E. ;

Gupta, Ravindra K. .

NATURE, 2021, 592 (7853) :277-+

[19] Evaluation of Seropositivity Following BNT162b2 Messenger RNA Vaccination for SARS-CoV-2 in Patients Undergoing Treatment for Cancer [J].

Massarweh, Amir ;

Eliakim-Raz, Noa ;

Stemmer, Amos ;

Levy-Barda, Adva ;

Yust-Katz, Shlomit ;

Zer, Alona ;

Benouaich-Amiel, Alexandra ;

Ben-Zvi, Haim ;

Moskovits, Neta ;

Brenner, Baruch ;

Bishara, Jihad ;

Yahav, Dafna ;

Tadmor, Boaz ;

Zaks, Tal ;

Stemmer, Salomon M. .

JAMA ONCOLOGY, 2021, 7 (08) :1133-1140

[20] Safety and immunogenicity of one versus two doses of the COVID-19 vaccine BNT162b2 for patients with cancer: interim analysis of a prospective observational study [J].

Monin, Leticia ;

Laing, Adam G. ;

Munoz-Ruiz, Miguel ;

McKenzie, Duncan R. ;

Del Barrio, Irene Del Molino ;

Alaguthurai, Thanussuyah ;

Domingo-Vila, Clara ;

Hayday, Thomas S. ;

Graham, Carl ;

Seow, Jeffrey ;

Abdul-Jawad, Sultan ;

Kamdar, Shraddha ;

Harvey-Jones, Elizabeth ;

Graham, Rosalind ;

Cooper, Jack ;

Khan, Muhammad ;

Vidler, Jennifer ;

Kakkassery, Helen ;

Sinha, Shubhankar ;

Davis, Richard ;

Dupont, Liane ;

Quijorna, Isaac Francos ;

O'Brien-Gore, Charlotte ;

Lee, Puay Ling ;

Eum, Josephine ;

Poole, Maria Conde ;

Joseph, Magdalene ;

Davies, Daniel ;

Wu, Yin ;

Swampillai, Angela ;

North, Bernard, V ;

Montes, Ana ;

Harries, Mark ;

Rigg, Anne ;

Spicer, James ;

Malim, Michael H. ;

Fields, Paul ;

Patten, Piers ;

Di Rosa, Francesca ;

Papa, Sophie ;

Tree, Timothy ;

Doores, Katie J. ;

Hayday, Adrian C. ;

Irshad, Sheeba .

LANCET ONCOLOGY, 2021, 22 (06) :765-778

← 1 2 3 4 →