Suboptimal Response to Coronavirus Disease 2019 Messenger RNA Vaccines in Patients With Hematologic Malignancies: A Need for Vigilance in the Postmasking Era

被引：57

作者：

Agha, Mounzer E. ^{[1
]}

Blake, Maggie ^{[1
]}

Chilleo, Charles ^{[3
]}

Wells, Alan ^{[2
]}

Haidar, Ghady ^{[4
]}

机构：

[1] Univ Pittsburgh, Med Ctr, Hillman Canc Ctr, Pittsburgh, PA USA

[2] Univ Pittsburgh, Sch Med, Dept Pathol, Pittsburgh, PA USA

[3] Univ Pittsburgh, Med Ctr, Clin Labs, Pittsburgh, PA USA

[4] Univ Pittsburgh, Div Infect Dis, Sch Med, Pittsburgh, PA USA

来源：

OPEN FORUM INFECTIOUS DISEASES | 2021年 / 8卷 / 07期

基金：

美国国家卫生研究院;

关键词：

antibody; COVID; 19; vaccine; hematological malignancy; SARS; CoV; 2; COVID-19;

D O I：

10.1093/ofid/ofab353

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We measured severe acute respiratory syndrome coronavirus 2 immunoglobulin G responses in 67 patients with hematological malignancies after 2 messenger RNA vaccine doses. Forty-six percent were nonresponders; patients with B-cell chronic lymphocytic leukemia were at highest risk (77% nonresponders). Patients with hematological malignancies should continue wearing masks and socially distancing. Studies of revaccination, boosters, and humoral immune correlates of protection are needed.

引用

页数：5

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