ACTIVIN RECEPTOR-LIKE KINASE AND THE INSULIN GENE

被引：8
|
作者：
Watanabe, Rie [1 ]
机构：
[1] Kyoto Univ, Grad Sch Med, Dept Diabet & Clin Nutr, Kyoto 606, Japan
来源：
ACTIVINS AND INHIBINS | 2011年 / 85卷
关键词：
TRANSFORMING-GROWTH-FACTOR; SERINE-THREONINE KINASE; PANCREATIC BETA-CELLS; EMBRYONIC STEM-CELLS; BONE MORPHOGENETIC PROTEIN; TRANSCRIPTION CONTROL REGION; HUMAN ENDOTHELIAL-CELLS; TGF-BETA; II RECEPTOR; SERINE/THREONINE KINASE;
D O I：
10.1016/B978-0-12-385961-7.00001-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The biological responses of the transforming growth factor-beta (TGF-beta) superfamily, which includes Activins and Nodal, are induced by activation of a receptor complex and Smads. A type I receptor, which is a component of the complex, is known as an activin receptor-like kinase (ALK); currently seven ALKs (ALK1-ALK7) have been identified in humans. Activins signaling, which is mediated by ALK4 and 7 together with ActRIIA and IIB, plays a critical role in glucose-stimulated insulin secretion, development/neogenesis, and glucose homeostatic control of pancreatic endocrine cells; the insulin gene is regulated by these signaling pathways via ALK7, which is a receptor for Activins AB and B and Nodal. This review discusses signal transduction of ALKs in pancreatic endocrine cells and the role of ALKs in insulin gene regulation. (C) 2011 Elsevier Inc.
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页码：1 / 27
页数：27
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