Histologic and Immunohistologic Characterization of Skin Localization of Myeloid Disorders A Study of 173 Cases

被引：56

作者：

Benet, Claire ^{[1
]}

Gomez, Aurelie ^{[2
]}

Aguilar, Claire ^{[5
]}

Delattre, Claire ^{[6
]}

Vergier, Beatrice ^{[3
]}

Beylot-Barry, Marie ^{[4
]}

Fraitag, Sylvie

Carlotti, Agnes ^{[7
]}

Dechelotte, Pierre ^{[8
]}

Hospital, Valerie ^{[9
,10
]}

d'Incan, Michel ^{[9
]}

Costes, Valerie

Dereure, Olivier ^{[11
]}

Ortonne, Nicolas ^{[12
]}

Bagot, Martine ^{[13
]}

Laroche, Liliane ^{[14
]}

Blom, Astrid ^{[14
]}

Dalac, Sophie ^{[15
]}

Petrella, Tony ^{[1
,16
]}

机构：

[1] CHU, Anat Pathol Lab, Dijon, France

[2] Hop Haut Leveque, CHU Bordeaux, Hematol Serv, Bordeaux, France

[3] Hop Haut Leveque, CHU Bordeaux, Anat Pathol Lab, Bordeaux, France

[4] Hop Haut Leveque, CHU Bordeaux, Dermatol Serv, Bordeaux, France

[5] Hop Necker Enfants Malad, AP HP, Anat Pathol Lab, Paris, France

[6] CHU Lille, Lille, France

[7] Hop Cochin, AP HP, Paris, France

[8] Hop Estaing, CHU Clermont Ferrand, Serv Anat Pathol, Clermont Ferrand, France

[9] Hop Estaing, CHU Clermont Ferrand, Dermatol Serv, Clermont Ferrand, France

[10] CHU Montpellier, Anat Pathol Lab, Montpellier, France

[11] CHU Montpellier, Dermatol Serv, Montpellier, France

[12] Hop Henri Mondor, AP HP, Dept Pathol, Creteil, France

[13] Hop St Louis, AP HP, Dermatol Serv, Paris, France

[14] Hop Avicenne, AP HP, Bobigny, France

[15] CHU, Dijon, France

[16] Pathol Ctr, Dijon, France

来源：

AMERICAN JOURNAL OF CLINICAL PATHOLOGY | 2011年 / 135卷 / 02期

关键词：

Myeloid leukemia cutis; Morphology; Immunohistochemistry; CD68; CD33; CD123; Chronic myelomonocytic leukemia; Plasmacytoid dendritic cell; MONOCYTES/INTERFERON-PRODUCING CELLS; CHRONIC MYELOMONOCYTIC LEUKEMIA; ACUTE MONOCYTIC LEUKEMIA; CUTIS; LYMPHOMA; CLASSIFICATION; EXPRESSION; PATIENT; TUMOR; CD56;

D O I：

10.1309/AJCPFMNYCVPDEND0

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

A retrospective analysis of 173 skin biopsy specimens of myeloid leukemia cutis (MLC) was performed to determine histologic and immunophenotypic criteria that could distinguish the varied myeloid disorders from one another. For the study, 11 relevant histologic items were scored and 12 antigens were studied (CD68 [KP1], CD163, CD14, CD4, myeloperoxidase [MPO], CD33, CD117, CD34, CD56, MIB-1, CD303, and CD123). Underlying myeloid disorders were essentially acute myeloid leukemias (65.3%), chronic myelomonocytic leukemias (11.0%), and refractory anemia (10.4%). Skin lesions were de novo in 7.5%, concurrent in 26.6%, and subsequent in 60.7%. Several morphologic characteristics (density, size of tumor cells, inflammatory background) were statistically useful in distinguishing between varied myeloid disorders. De novo MLCs displayed a specific morphologic profile. Association of CD68, CD33, and MPO could diagnose 100% of the cases of MLC. However, the immunohistochemical panel could not distinguish between the varied underlying myeloid disorders, with the exception that CD123 was particularly powerful in recognizing chronic myelomonocytic leukemia and also permitted reclassification of 4 cases as blastic plasmacytoid dendritic cell neoplasm.

引用

页码：278 / 290

页数：13

共 39 条

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