Prognostic value of visfatin in various human malignancies: A systematic review and meta-analysis

被引:8
|
作者
Mohammadi, Masoumeh [1 ]
Moradi, Ali [2 ]
Farhadi, Javad [3 ]
Akbari, Abolfazl [4 ]
Pourmandi, Shokoufeh [5 ]
Mehrad-Majd, Hassan [6 ]
机构
[1] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Cellular & Mol Endocrine Res Ctr, Tehran, Iran
[2] Mashhad Univ Med Sci, Orthoped Res Ctr, Mashhad, Razavi Khorasan, Iran
[3] Islamic Azad Univ, Neyshabur Branch, Dept Biochem & Mol Biol, Neyshabur, Iran
[4] Iran Univ Med Sci, Colorectal Res Ctr, Tehran, Iran
[5] Mashhad Univ Med Sci, Fac Med, Student Res Comm, Mashhad, Razavi Khorasan, Iran
[6] Mashhad Univ Med Sci, Canc Mol Pathol Res Ctr, Mashhad, Razavi Khorasan, Iran
关键词
Visfatin; Cancer; Prognostic marker; Meta-analysis; GASTRIC-CANCER; BREAST-CANCER; POOR-PROGNOSIS; EXPRESSION; CELL; ADIPOCYTOKINES; OBESITY; PROLIFERATION; ADIPOKINES; BIOMARKERS;
D O I
10.1016/j.cyto.2019.154964
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Although numerous studies have shown that visfatin is linked to several cancers, its prognostic value is still unclear. This first comprehensive meta-analysis was performed to evaluate the prognostic effect of visfatin in cancer patients. A systematic search was conducted for relevant studies in health-related electronic databases up to May 2019. The pooled hazard ratios (HRs) and ORs with 95% confidence intervals (Cls) for total and stratified analyses were calculated to demonstrate the prognostic value of visfatin expression level in cancer patients. Heterogeneity and publication bias were also investigated. A total of 14 eligible studies with 1616 patients were included in the current meta-analysis. Pooling results revealed that, high visfatin expression was significantly associated with poorer overall survival (OS) (HR = 2.43, 95% CI 1.64-3.62, P < 0.001). Elevated visfatin level was also correlated with positive lymph node metastasis (OR = 2.45, 95% CI 1.43-4.17, P <= 0.001), positive distance metastasis (OR = 2014, 95% CI 1.25-3.69, P <= 0.001), advanced tumor stage (OR = 3.01, 95% CI 1.91-7.72, P <= 0.001), and larger tumor size (OR = 1.99, 95% CI 1.49-2.69, P <= 0.001). Our meta-results indicates that altered visfatin expression is a potential indicator of poor clinical outcomes in tumor patients, suggesting that high visfatin expression may serve as a potential biomarker of poor prognosis and metastasis in cancers.
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页数:9
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