Goat's Milk as a Potential Anti-proliferative against Colon Cancer Cell Lines

被引：1

作者：

Dahlan, Nurhashimah ^{[1
]}

Baharum, Jamila Khayrin ^{[1
]}

Ridzwan, Norhaslinda ^{[1
]}

Jumli, Mimie Noratiqah ^{[1
]}

Abd Hadi, Norhayati ^{[1
]}

Arshad, Roslan ^{[2
]}

Baig, Atif Amin ^{[3
]}

Rohin, Mohd Adzim Khalili ^{[1
]}

Abu Bakar, Che Abdullah ^{[2
]}

Latif, Ahmad Zubaidi A. ^{[3
]}

机构：

[1] Univ Sultan Zainal Abidin, Fac Hlth Sci, Sch Nutr & Dietet, Gong Badak Campus, Kuala Nerus 21300, Terengganu Daru, Malaysia

[2] Univ Sultan Zainal Abidin, Fac Bioresources & Food Ind, Besut Campus, Besut 22200, Terengganu Daru, Malaysia

[3] Univ Sultan Zainal Abidin, Fac Med, Med Campus,Jalan Sultan Mahmud, Kuala Terengganu 20400, Terengganu Daru, Malaysia

来源：

JOURNAL OF PHARMACEUTICAL RESEARCH INTERNATIONAL | 2021年 / 33卷 / 44A期

关键词：

Anti-proliferative; goat milk; colon cancer; MTT assay; FATTY-ACIDS; APOPTOSIS;

D O I：

10.9734/JPRI/2021/v33i44A32642

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Aim: To investigate anti-proliferative effect of fresh and pasteurized goat milk against colon cancer cell lines (HT-29, HCT-116, CT-26). Study Design: Experimental study. Place and Duration of Study: Central Laboratory, Tissue Culture Laboratory, Universiti Sultan Zainal Abidin, Terengganu between January 2020 and April 2020. Methodology: Samples comprised of two types goat milk, which were fresh and pasteurized in powder form. The samples were analysed for the anti-proliferative effect by MTT assay, and IC50 value was determined. Then, cell apoptotic changes were observed by light inverted microscope by 24, 48 and 72 hours. Results: Experimental data showed that the fresh sample produce the highest yield (9.40%) than the pasteurized sample (7.17%). The fresh sample yielded the most potent cytotoxic value (0.28 +/- 0.03), followed by pasteurized sample with value IC50 0.32 +/- 0.02 against HCT-116 cells. Then, the anti-proliferative effect was observed on cell apoptotic changes by reduction of cell volume, cell densed, and presence of fragmentation and apoptotic bodies at 24, 48 and 72 hours treatment. Conclusion: In conclusion, the fresh sample of goat milk yielded the potent anti-proliferative effect than pasteurized sample.

引用

页码：493 / 501

页数：9

共 50 条

[41] In vitro anti-proliferative activity of selected nutraceutical compounds in human cancer cell lines
Nibret, Endalkachew
Krstin, Sonja
Wink, Michael
BMC RESEARCH NOTES, 2021, 14 (01)
[42] ANTI-PROLIFERATIVE EFFECT OF CISPLATIN, DOXORUBICIN AND EPIRUBICIN IN TWO PROSTATE CANCER CELL LINES
Mamede, A. C.
Abrantes, A. M.
Pedrosa, L.
Pires, A. S.
Maia, C. J.
Botelho, M. F.
ANNALS OF ONCOLOGY, 2012, 23 : 28 - 28
[43] Anti-proliferative activity of Artemisia marschalliana on cancerous cell lines
Forouhandeh, Haleh
Tarhriz, Vahideh
Zadehkamand, Masoumeh
Asgharian, Parina
BMC COMPLEMENTARY MEDICINE AND THERAPIES, 2023, 23 (01)
[44] Anti-proliferative effects of cCMP in mammary carcinoma cell lines
Wolter, S.
Broemsen, T.
Sharifi, S.
Gluesen, M.
Seifert, R.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2020, 393 (SUPPL 1) : 67 - 67
[45] Interferon-alpha promotes the anti-proliferative effect of Erlotinib (OSI-774) on human colon cancer cell lines
Yang, JL
Qu, XJ
Russell, PJ
Goldstein, D
CANCER LETTERS, 2005, 225 (01) : 61 - 74
[46] Duramycin demonstrates anti-proliferative properties and induces apoptosis in pancreatic cancer cell lines
Welsh, J.
Yates, K. R.
Udegbunam, N. O.
Greenman, J.
Maraveyas, A.
Madden, L. A.
IMMUNOLOGY, 2011, 135 : 146 - 146
[47] Synthesis of novel benzofurocoumarin analogues and their anti-proliferative effect on human cancer cell lines
Francisco, Carla S.
Rodrigues, Ligia R.
Cerqueira, Nuno M. F. S. A.
Oliveira-Campos, Ana M. F.
Rodrigues, Ligia M.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2012, 47 : 370 - 376
[48] In vitro anti-proliferative effects of Zuojinwan on eight kinds of human cancer cell lines
Lina Xu
Yan Qi
Linlin Lv
Youwei Xu
Lingli Zheng
Lianhong Yin
Kexin Liu
Xu Han
Yanyan Zhao
Jinyong Peng
Cytotechnology, 2014, 66 : 37 - 50
[49] In vitro anti-proliferative effects of Zuojinwan on eight kinds of human cancer cell lines
Xu, Lina
Qi, Yan
Lv, Linlin
Xu, Youwei
Zheng, Lingli
Yin, Lianhong
Liu, Kexin
Han, Xu
Zhao, Yanyan
Peng, Jinyong
CYTOTECHNOLOGY, 2014, 66 (01) : 37 - 50
[50] Synergistic anti-proliferative effects of gambogic acid with docetaxel in gastrointestinal cancer cell lines
Zou, Zhengyun
Xie, Li
Wei, Jia
Yu, Lixia
Qian, Xiaoping
Chen, Junhao
Wang, Tingting
Liu, Baorui
BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2012, 12

← 1 2 3 4 5 →