Anti-apoptotic versus pro-apoptotic signal transduction:: Checkpoints and stop signs along the road to death

被引：143

作者：

Jarpe, MB

Widmann, C

Knall, C

Schlesinger, TK

Gibson, S

Yujiri, T

Fanger, GR

Gelfand, EW

Johnson, GL ^{[1
]}

机构：

[1] Natl Jewish Med & Res Ctr, Program Mol Signal Transduct, Div Basic Sci, Denver, CO 80206 USA

[2] Natl Jewish Med & Res Ctr, Dept Pediat, Denver, CO 80206 USA

[3] Univ Colorado, Hlth Sci Ctr, Dept Pharmacol, Denver, CO 80262 USA

来源：

ONCOGENE | 1998年 / 17卷 / 11期

关键词：

signal transduction; cell death;

D O I：

10.1038/sj.onc.1202183

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The activation of caspases is a final commitment step for apoptosis. It is now evident that signal transduction pathways involving specific protein kinases modulate the apoptotic response. Both pro-apoptotic and anti-apoptotic pathways integrate environmental cues that control the decision to undergo apoptosis. Pro- and anti-apoptotic signal pathways regulate the activation of the caspases. In this review we describe our current understanding of apoptotic signal transduction.

引用

收藏

页码：1475 / 1482

页数：8

相关论文

共 79 条

[11] Regulation of neuronal survival by the serine-threonine protein kinase Akt [J].

Dudek, H ;

Datta, SR ;

Franke, TF ;

Birnbaum, MJ ;

Yao, RJ ;

Cooper, GM ;

Segal, RA ;

Kaplan, DR ;

Greenberg, ME .

SCIENCE, 1997, 275 (5300) :661-665

[12] Proteolytic activation of protein kinase C delta by an ICE-like protease in apoptotic cells [J].

Emoto, Y ;

Manome, Y ;

Meinhardt, G ;

Kisaki, H ;

Kharbanda, S ;

Robertson, M ;

Ghayur, T ;

Wong, WW ;

Kamen, R ;

Weichselbaum, R ;

Kufe, D .

EMBO JOURNAL, 1995, 14 (24) :6148-6156

[13] CELLULAR-RESPONSES TO DNA-DAMAGE - CELL-CYCLE CHECKPOINTS, APOPTOSIS AND THE ROLES OF P53 AND ATM [J].

ENOCH, T ;

NORBURY, C .

TRENDS IN BIOCHEMICAL SCIENCES, 1995, 20 (10) :426-430

[14] Crk is required for apoptosis in Xenopus egg extracts [J].

Evans, EK ;

Lu, W ;

Strum, SL ;

Mayer, BJ ;

Kornbluth, S .

EMBO JOURNAL, 1997, 16 (02) :230-241

[15] PI3K: Downstream AKTion blocks apoptosis [J].

Franke, TF ;

Kaplan, DR ;

Cantley, LC .

CELL, 1997, 88 (04) :435-437

[16] Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate [J].

Franke, TF ;

Kaplan, DR ;

Cantley, LC ;

Toker, A .

SCIENCE, 1997, 275 (5300) :665-668

[17] p38 mitogen-activated protein kinase-dependent and -independent intracellular signal transduction pathways leading to apoptosis in human neutrophils [J].

Frasch, SC ;

Nick, JA ;

Fadok, VA ;

Bratton, DL ;

Worthen, GS ;

Henson, PM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (14) :8389-8397

[18] High affinity binding of inositol phosphates and phosphoinositides to the Pleckstrin homology domain of RAC protein kinase B and their influence on kinase activity [J].

Frech, M ;

Andjelkovic, M ;

Ingley, E ;

Reddy, KK ;

Falck, JR ;

Hemmings, BA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (13) :8474-8481

[19] A role for Jun-N-Terminal kinase in anoikis; Suppression by bcl-2 and crmA [J].

Frisch, SM ;

Vuori, K ;

Kelaita, D ;

Sicks, S .

JOURNAL OF CELL BIOLOGY, 1996, 135 (05) :1377-1382

[20] Fibroblast growth factor-2 suppression of tumor necrosis factor alpha-mediated apoptosis requires Ras and the activation of mitogen-activated protein kinase [J].

Gardner, AM ;

Johnson, GL .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (24) :14560-14566

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