Anti-apoptotic versus pro-apoptotic signal transduction:: Checkpoints and stop signs along the road to death

被引：143

作者：

Jarpe, MB

Widmann, C

Knall, C

Schlesinger, TK

Gibson, S

Yujiri, T

Fanger, GR

Gelfand, EW

Johnson, GL ^{[1
]}

机构：

[1] Natl Jewish Med & Res Ctr, Program Mol Signal Transduct, Div Basic Sci, Denver, CO 80206 USA

[2] Natl Jewish Med & Res Ctr, Dept Pediat, Denver, CO 80206 USA

[3] Univ Colorado, Hlth Sci Ctr, Dept Pharmacol, Denver, CO 80262 USA

来源：

ONCOGENE | 1998年 / 17卷 / 11期

关键词：

signal transduction; cell death;

D O I：

10.1038/sj.onc.1202183

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The activation of caspases is a final commitment step for apoptosis. It is now evident that signal transduction pathways involving specific protein kinases modulate the apoptotic response. Both pro-apoptotic and anti-apoptotic pathways integrate environmental cues that control the decision to undergo apoptosis. Pro- and anti-apoptotic signal pathways regulate the activation of the caspases. In this review we describe our current understanding of apoptotic signal transduction.

引用

页码：1475 / 1482

页数：8

共 79 条

[1] Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase B alpha [J].