ANIMAL MODELS IN THE STUDY OF THE UNFOLDED PROTEIN RESPONSE

被引：13

作者：

Bommiasamy, Hemamalini ^{[1
]}

Popko, Brian ^{[1
]}

机构：

[1] Univ Chicago, Dept Neurol, Ctr Peripheral Neuropathy, Chicago, IL 60637 USA

来源：

METHODS IN ENZYMOLOGY, VOL 491: UNFOLDED PROTEIN RESPONSE AND CELLULAR STRESS, PT C | 2011年 / 491卷

关键词：

ENDOPLASMIC-RETICULUM STRESS; TRANSCRIPTION FACTOR XBP-1; INDUCED GENE-EXPRESSION; PERK EIF2-ALPHA KINASE; NF-Y CBF; ER STRESS; MESSENGER-RNA; TRANSLATIONAL REGULATION; CELL-SURVIVAL; CHOP GADD153;

D O I：

10.1016/B978-0-12-385928-0.00006-7

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The endoplasmic reticulum, a highly dynamic and complex organelle, is the site for synthesis, folding, and modification of transmembrane and secretory proteins. Any disruptions to the endoplasmic reticulum such as an accumulation of misfolded or unfolded proteins results in activation of the unfolded protein response (UPR). The UPR is comprised of three distinct signal transduction pathways that work to restore homeostasis to the endoplasmic reticulum. This review summarizes select mouse models available to study the UPR and the information learned from the analyses of these models.

引用

页码：91 / 109

页数：19

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