Non-synchronized endometrium and its correction in non-ovulatory cryopreserved embryo transfer cycles

被引：23
作者：
Gomaa, Hala [1 ,2 ,3 ]
Casper, Robert F. [1 ,2 ,3 ]
Esfandiari, Navid [1 ,2 ]
Bentov, Yaakov [1 ,2 ,3 ]
机构：
[1] Toronto Ctr Adv Reprod Technol, Toronto, ON M5X 2S9, Canada
[2] Univ Toronto, Dept Obstet & Gynecol, Div Reprod Sci, Toronto, ON, Canada
[3] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada
来源：
REPRODUCTIVE BIOMEDICINE ONLINE | 2015年 / 30卷 / 04期
关键词：
cryopreserved embryo transfer; endometrial dating; pregnancy; window of implantation; PROGESTERONE; IMPLANTATION; BIOPSY; RECEPTIVITY; INDUCTION; IMPACT; PHASE; TIME;
D O I：
10.1016/j.rbmo.2014.12.005
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
The aim of this case series study was to investigate the effect of adjusting the length of progesterone exposure on clinical pregnancy rates in cryopreserved embryo transfer cycles of patients with out-of-phase classic endometrial dating. Eighty infertile women with previous implantation failure and good-quality embryos underwent endometrial biopsy before cryopreserved embryo transfer and were included in this study. The main outcome measures were clinical pregnancy rate and histologic endometrial dating. After adjusting the length of progesterone exposure according to endometrial dating, a significantly higher implantation rate was observed in blastocyst transfers (P = 0.02) and the clinical pregnancy rate for all cycles was 36.4%, similar to that in patients with in-phase endometrium (22.5%). In conclusion, the use of classic histologic endometrial dating to estimate the timing of the window of implantation and to adjust progesterone exposure accordingly may increase the implantation rate in frozen embryo transfer cycles. (C) 2014 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：378 / 384
页数：7
相关论文
共 41 条
  • [1] Endometrial receptivity markers, the journey to successful embryo implantation
    Achache, Hanna
    Revel, Ariel
    [J]. HUMAN REPRODUCTION UPDATE, 2006, 12 (06) : 731 - 746
  • [2] Impact of physician performing embryo transfer on pregnancy rates in an assisted reproductive program
    Angelini, Antonio
    Brusco, Gian Francesco
    Barnocchi, Nicoletta
    El-Danasouri, Imam
    Pacchiarotti, Arianna
    Selman, Helmy A.
    [J]. JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, 2006, 23 (7-8) : 329 - 332
  • [3] Morphological changes and protein secretion induced by progesterone in the endometrium during the luteal phase in preparation for nidation
    Bergeron, C
    [J]. HUMAN REPRODUCTION, 2000, 15 : 119 - 128
  • [4] SONOGRAPHIC EVALUATION OF THE ENDOMETRIUM IN INVITRO FERTILIZATION IVF CYCLES - A WAY TO PREDICT PREGNANCY
    BERGH, C
    HILLENSJO, T
    NILSSON, L
    [J]. ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, 1992, 71 (08) : 624 - 628
  • [5] BERGH PA, 1992, FERTIL STERIL, V58, P537
  • [6] Implantation failure: molecular mechanisms and clinical treatment
    Cakmak, Hakan
    Taylor, Hugh S.
    [J]. HUMAN REPRODUCTION UPDATE, 2011, 17 (02) : 242 - 253
  • [7] It's time to pay attention to the endometrium
    Casper, Robert F.
    [J]. FERTILITY AND STERILITY, 2011, 96 (03) : 519 - 521
  • [8] Histological dating of timed endometrial biopsy tissue is not related to fertility status
    Coutifaris, C
    Myers, ER
    Guzick, DS
    Diamond, MP
    Carson, SA
    Legro, RS
    McGovern, PG
    Schlaff, WD
    Carr, BR
    Steinkampf, MP
    Silva, S
    Vogel, DL
    Leppert, PC
    [J]. FERTILITY AND STERILITY, 2004, 82 (05) : 1264 - 1272
  • [9] Cutting Rachel, 2008, Hum Fertil (Camb), V11, P131, DOI 10.1080/14647270802302629
  • [10] Ovarian Hyperstimulation Syndrome Prevention Strategies: Cryopreservation of All Embryos
    D'Angelo, Arianna
    [J]. SEMINARS IN REPRODUCTIVE MEDICINE, 2010, 28 (06) : 513 - 518
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