Stem cell plasticity: Learning from hepatogenic differentiation strategies

被引：44

作者：

Banas, Agnieszka ^{[1
]}

Yamamoto, Yusuke ^{[1
,2
]}

Teratani, Takumi ^{[1
]}

Ochiya, Takahiro ^{[1
]}

机构：

[1] Natl Inst Canc Res, Head Sect Studies Metasis, Tokyo 1040045, Japan

[2] Waseda Univ, Sch Educ, Dept Biol, Tokyo, Japan

来源：

DEVELOPMENTAL DYNAMICS | 2007年 / 236卷 / 12期

关键词：

stem cells; hepatocytes; plasticity; differentiation;

D O I：

10.1002/dvdy.21330

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Many studies on stem cell plasticity are challenging the concept that stem cells contain an intrinsically predefined, unidirectional differentiation program. This means that the developmental fate of a stem cell is dependent on the general potential of the cell (pre-determined stem cell fate) as well as on microenvironmental cues, such as stimuli from growth factors (stem cell niche). Here, we reviewed reports that examined the hepatocyte differentiation ability of stem cells from two different sources: embryonic stem cells and adult stem cells. All of those stem cells revealed the ability to give rise to hepatocyte-like cells using different induction strategies. However, it is still not clear which of those stem cells would be the best source for hepatocyte replacement or which would be the best protocol. We herein present the current knowledge regarding available protocols and factors used in order to obtain functional hepatocytes from stem cells. Developmental Dynamics 236:3228-3241, 2007. (c) 2007 Wiley-Liss, Inc.

引用

页码：3228 / 3241

页数：14

共 101 条

[11] Embryoid-body cells derived from a mouse embryonic stem cell line show differentiation into functional hepatocytes [J].

Chinzei, R ;

Tanaka, Y ;

Shimizu-Saito, K ;

Hara, Y ;

Kakinuma, S ;

Watanabe, M ;

Teramoto, K ;

Arii, S ;

Takase, K ;

Sato, C ;

Terada, N ;

Teraoka, H .

HEPATOLOGY, 2002, 36 (01) :22-29

[12] Isolation of multipotent progenitor cells from human fetal liver capable of differentiating into liver and mesenchymal lineages [J].

Dan, Y. Y. ;

Riehle, K. J. ;

Lazaro, C. ;

Teoh, N. ;

Haque, J. ;

Campbell, J. S. ;

Fausto, N. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (26) :9912-9917

[13] Isolation of amniotic stem cell lines with potential for therapy [J].

De Coppi, Paolo ;

Bartsch, Georg, Jr. ;

Siddiqui, M. Minhaj ;

Xu, Tao ;

Santos, Cesar C. ;

Perin, Laura ;

Mostoslavsky, Gustavo ;

Serre, Angeline C. ;

Snyder, Evan Y. ;

Yoo, James J. ;

Furth, Mark E. ;

Soker, Shay ;

Atala, Anthony .

NATURE BIOTECHNOLOGY, 2007, 25 (01) :100-106

[14] Origin and differentiation of human and murine stroma [J].

Dennis, JE ;

Charbord, P .

STEM CELLS, 2002, 20 (03) :205-214

[15] ESTABLISHMENT IN CULTURE OF PLURIPOTENTIAL CELLS FROM MOUSE EMBRYOS [J].

EVANS, MJ ;

KAUFMAN, MH .

NATURE, 1981, 292 (5819) :154-156

[16] A PRECURSOR PRODUCT RELATIONSHIP EXISTS BETWEEN OVAL CELLS AND HEPATOCYTES IN RAT-LIVER [J].

EVARTS, RP ;

NAGY, P ;

MARSDEN, E ;

THORGEIRSSON, SS .

CARCINOGENESIS, 1987, 8 (11) :1737-1740

[17] Using human adipose tissue-derived mesenchymal stem cells as salvage therapy for hepatic graft-versus-host disease resembling acute hepatitis [J].

Fang, B. ;

Song, Y. ;

Zhao, R. C. ;

Han, Q. ;

Lin, Q. .

TRANSPLANTATION PROCEEDINGS, 2007, 39 (05) :1710-1713

[18]

FARBER E, 1956, CANCER RES, V16, P142

[19] Liver regeneration [J].

Fausto, N ;

Campbell, JS ;

Riehle, KJ .

HEPATOLOGY, 2006, 43 (02) :S45-S53

[20] Liver regeneration and repair: Hepatocytes, progenitor cells, and stem cells [J].

Fausto, N .

HEPATOLOGY, 2004, 39 (06) :1477-1487

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