Stem cell plasticity: Learning from hepatogenic differentiation strategies

被引：44

作者：

Banas, Agnieszka ^{[1
]}

Yamamoto, Yusuke ^{[1
,2
]}

Teratani, Takumi ^{[1
]}

Ochiya, Takahiro ^{[1
]}

机构：

[1] Natl Inst Canc Res, Head Sect Studies Metasis, Tokyo 1040045, Japan

[2] Waseda Univ, Sch Educ, Dept Biol, Tokyo, Japan

来源：

DEVELOPMENTAL DYNAMICS | 2007年 / 236卷 / 12期

关键词：

stem cells; hepatocytes; plasticity; differentiation;

D O I：

10.1002/dvdy.21330

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Many studies on stem cell plasticity are challenging the concept that stem cells contain an intrinsically predefined, unidirectional differentiation program. This means that the developmental fate of a stem cell is dependent on the general potential of the cell (pre-determined stem cell fate) as well as on microenvironmental cues, such as stimuli from growth factors (stem cell niche). Here, we reviewed reports that examined the hepatocyte differentiation ability of stem cells from two different sources: embryonic stem cells and adult stem cells. All of those stem cells revealed the ability to give rise to hepatocyte-like cells using different induction strategies. However, it is still not clear which of those stem cells would be the best source for hepatocyte replacement or which would be the best protocol. We herein present the current knowledge regarding available protocols and factors used in order to obtain functional hepatocytes from stem cells. Developmental Dynamics 236:3228-3241, 2007. (c) 2007 Wiley-Liss, Inc.

引用

页码：3228 / 3241

页数：14

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