Gas-Liquid Segmented Flow Microfluidics for Screening Copper/TEMPO-Catalyzed Aerobic Oxidation of Primary Alcohols

被引：31
|
作者：
Vanoye, Laurent [1 ]
Pablos, Mertxe [1 ]
de Bellefon, Claude [1 ]
Favre-Reguillon, Alain [1 ,2 ]
机构：
[1] CPE Lyon, Lab Genie Proc Catalyt, F-69100 Villeurbanne, France
[2] CASER SITI, Conservatoire Natl Arts & Metiers, F-75003 Paris, France
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2015年 / 357卷 / 04期
关键词：
aerobic oxidation; alcohols; copper; flow chemistry; 2,2,6,6-tetramethylpiperidine N-oxyl (TEMPO); COPPER(I)/TEMPO CATALYST; ROOM-TEMPERATURE; AQUEOUS AMMONIA; PROCESS WINDOWS; ALDEHYDES; REACTORS; MECHANISM; AMINES; OXYGEN; NITRILES;
D O I：
10.1002/adsc.201400925
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Aerobic oxidation using a combination of copper salts and 2,2,6,6-tetramethylpiperidine N-oxyl (TEMPO) represent useful tools for organic synthesis and several closely related catalyst systems have been reported. To gain further insights, these catalytic systems were evaluated in a gas-liquid segmented flow device. The improvement of oxygen mass transfer has a significant influence on the turnover-limiting step. Hence, an improved catalytic system using copper(II) as copper source was implemented in a microreactor for the safe and efficient oxidation of primary alcohol.
引用
收藏
页码：739 / 746
页数：8
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