DNA Nanocages

DNA has been used in the construction of a variety of nanoscale structures. Of these, designed cage-like structures of sizes ranging from similar to 10 to similar to 100 nm and molecular weights of up to similar to 60 MDa have been. developed. These nanocages have been assembled using different strategies that include a one-pot approach, modular assembly, hierarchical self assembly, and the DNA origami technique. Such structures can be programmed to be reconfigurable via external triggers such as ligands, biomolecules, and pH. These objects provide a route to encapsulate proteins and nanoparticles and allow targeted delivery of these guests. With such versatile properties, DNA nanocages find applications in medicine, biotechnology, imaging, and materials science.