Heterogeneity of Mitochondrial Membrane Potential: A Novel Tool to Isolate and Identify Cancer Stem Cells from a Tumor Mass?

被引：32
作者：
Ye, Xiao-Qun [1 ]
Wang, Guang-Hui [1 ]
Huang, Gui-Jun [1 ]
Bian, Xiu-Wu [2 ,3 ]
Qian, Gui-Sheng [1 ]
Yu, Shi-Cang [1 ,2 ,3 ]
机构：
[1] Third Mil Med Univ, Affiliated Hosp 2, Inst Resp Dis, Chongqing 400038, Peoples R China
[2] Third Mil Med Univ, Southwest Hosp, Inst Pathol, Chongqing 400037, Peoples R China
[3] Third Mil Med Univ, Southwest Hosp, SW Canc Ctr, Chongqing 400037, Peoples R China
来源：
STEM CELL REVIEWS AND REPORTS | 2011年 / 7卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Cancer stem cell; Mitochondrial membrane potential; Tumorigenicity; Isolation; Differentiation status; Heterogeneity; SIDE POPULATION CELLS; SELF-RENEWAL; DIFFERENTIATION; APOPTOSIS; PROLIFERATION; PRECURSOR; DEATH; LINE; DNA; IDENTIFICATION;
D O I：
10.1007/s12015-010-9122-9
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
It is believed that cancer stem cells (CSCs) are precursors for the formation, development, and recurrence of malignant tumors. However, it has proven difficult to isolate and enrich these rare, undifferentiated cells from heterogeneous tumor masses. With some existing reports and preliminary results in mind, we hypothesized that the mitochondrial membrane potential within a tumor mass was heterogeneous and could be used as a tool to isolate and enrich CSCs.
引用
收藏
页码：153 / 160
页数：8
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