Evaluation of a screening tool for bleeding disorders in a US multisite cohort of women with menorrhagia

被引：35

作者：

Philipp, Claire S. ^{[1
]}

Faiz, Ambarina ^{[1
]}

Heit, John A. ^{[2
]}

Kouides, Peter A. ^{[3
,4
]}

Lukes, Andrea ^{[5
]}

Stein, Sidney F. ^{[6
]}

Byams, Vanessa ^{[7
]}

Miller, Connie H. ^{[7
]}

Kulkarni, Roshni ^{[7
,8
]}

机构：

[1] UMDNJ Robert Wood Johnson Med Sch, Div Hematol, New Brunswick, NJ 08903 USA

[2] Mayo Clin, Div Cardiovasc Dis, Rochester, MN USA

[3] Univ Rochester, Sch Med, Rochester Gen Hosp, Rochester, NY USA

[4] Univ Rochester, Sch Med, Mary M Gooley Hemophilia Ctr, Rochester, NY USA

[5] Duke Univ, Sch Med, Dept Obstet & Gynecol, Durham, NC USA

[6] Emory Univ, Sch Med, Dept Hematol & Med Oncol, Atlanta, GA USA

[7] Ctr Dis Control & Prevent, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA

[8] Michigan State Univ, Dept Pediat & Human Dev, E Lansing, MI 48824 USA

来源：

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 2011年 / 204卷 / 03期

关键词：

bleeding disorder; ferritin; hemostatic evaluation; menorrhagia; VON-WILLEBRAND-DISEASE; BLOOD-LOSS; PREVALENCE; TYPE-1; MANAGEMENT;

D O I：

10.1016/j.ajog.2010.10.897

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

OBJECTIVE: The purpose of this study was to determine the usefulness of a simple screening tool for bleeding disorders in a multisite population of women with menorrhagia. STUDY DESIGN: Women with menorrhagia between the ages of 18 and 50 years from 6 geographically diverse US centers underwent hemostatic testing for bleeding disorders, complete blood cell count, and ferritin. A questionnaire that contained all elements of the 8-question screening tool was administered. Sensitivity of the screening tool, a screening tool with a pictorial blood assessment chart (PBAC) score of > 185, and a screening tool with serum ferritin were calculated for hemostatic disorders. RESULTS: Two hundred and seventeen women who were identified with a PBAC score of >= 100 participated in the study. The sensitivity of the screening tool was 89% for hemostatic defects, and sensitivity increased to 93% and 95% with a serum ferritin level of <= 20 ng/mL and a PBAC score of > 185, respectively. CONCLUSION: This study confirms the usefulness of a short screening tool for the stratification of women with menorrhagia for hemostatic evaluation.

引用

页数：7

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