Clomipramine Treatment and Repeated Restraint Stress Alter Parameters of Oxidative Stress in Brain Regions of Male Rats

被引：22

作者：

Balk, Rodrigo de Souza ^{[1
,2
]}

Bridi, Jessika Cristina ^{[1
]}

Portella, Rafael de Lima ^{[1
]}

Carvalho, Nelson Rodrigues ^{[1
]}

Dobrachinski, Fernando ^{[1
]}

da Silva, Michele Hinerasky ^{[1
]}

Amaral, Guilherme Pires ^{[1
]}

Mundstock Dias, Glaecir Roseni ^{[1
]}

Barbosa, Nilda de Vargas ^{[1
]}

Antunes Soares, Felix Alexandre ^{[1
]}

机构：

[1] Univ Fed Santa Maria, Ctr Ciencias Nat & Exatas, Dept Quim, BR-97105900 Santa Maria, RS, Brazil

[2] Univ fed Pampa, Dept Ciencias Saude, Uruguaiana, RS, Brazil

来源：

NEUROCHEMICAL RESEARCH | 2010年 / 35卷 / 11期

关键词：

Antioxidant enzymes; Repeated restraint stress; Clomipramine; Free radicals; Oxidative stress; GLUCOCORTICOID-RECEPTOR FUNCTION; IN-VITRO; FEEDING-BEHAVIOR; GLUTATHIONE; DAMAGE; NEURODEGENERATION; SYSTEMS; CELLS; ASSAY; VIVO;

D O I：

10.1007/s11064-010-0240-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This study aimed to compare the effects of repeated restraint stress alone and the combination with clomipramine treatment on parameters of oxidative stress in cerebral cortex, striatum and hippocampus of male rats. Animals were divided into control and repeated restraint stress, and subdivided into treated or not with clomipramine. After 40 days of stress and 27 days of clomipramine treatment with 30 mg/kg, the repeated restraint stress alone reduced levels of Na+, K+-ATPase in all tissues studied. The combination of repeated restraint stress and clomipramine increased the lipid peroxidation, free radicals and CAT activity as well as decreased levels of NP-SH in the tissues studied. However, Na+, K+-ATPase level decreased in striatum and cerebral cortex and the SOD activity increased in hippocampus and striatum. Results indicated that clomipramine may have deleterious effects on the central nervous system especially when associated with repeated restraint stress and chronically administered in non therapeutic levels.

引用

页码：1761 / 1770

页数：10

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