Analysis of the release process of phenylpropanolamine hydrochloride from ethylcellulose matrix granules IV.1) -: Evaluation of the controlled release properties for in vivo and in vitro release systems

被引：3

作者：

Fukui, Atsuko ^{[1
]}

Fujii, Ryuta ^{[1
]}

Yonezawa, Yorinobu ^{[2
]}

Sunada, Hisakazu ^{[2
]}

机构：

[1] Ryukakusan Co Ltd, Chiyoda Ku, Higashi Kanda, Tokyo 1010031, Japan

[2] Meijo Univ, Fac Pharm, Tempaku Ku, Nagoya, Aichi 4688503, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2007年 / 55卷 / 11期

关键词：

ethylcellulose matrix; phenylpropanolamine hydrochloride; square-root time law; cube-root law; simulation;

D O I：

10.1248/cpb.55.1569

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In the pharmaceutical preparation of a controlled release drug, it is very important and necessary to understand the release properties. The dissolution test is a very important and useful method for understanding and predicting drug-release properties. It was readily confirmed in the previous paper that the release process could be assessed quantitatively by a combination of the square-root time law and cube-root law equations for ethyleellulose (EC) matrix granules of phenylpropanolamine hydrochloride (PPA). In this paper EC layered granules were used in addition to EC matrix. The relationship between release property and the concentration of PPA in plasma after administration using beagle dogs were examined. Then it was confirmed that the correlativity for EC layered granules and EC matrix were similar each other. Therefore, it was considered that the dissolution test is useful for prediction of changes in concentration of PPA in the blood with time. And it was suggested that EC layered granules were suitable as a controlled release system as well as EC matrix.

引用

页码：1569 / 1573

页数：5