Proclaiming fate in the early mouse embryo

被引：10
作者：
Zernicka-Goetz, Magdalena [1 ]
机构：
[1] Univ Cambridge, Gurdon Inst, Cambridge CB2 1QR, England
来源：
NATURE CELL BIOLOGY | 2011年 / 13卷 / 02期
基金：
英国医学研究理事会; 英国惠康基金;
关键词：
1ST CLEAVAGE; TROPHECTODERM; BLASTOCYST; CDX2; SPECIFICATION; BLASTOMERES; POLARITY; 2-CELL; AXIS;
D O I：
10.1038/ncb0211-112
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
In the mouse embryo, the first differences between cells that result in distinct lineages have long been thought to arise only as a consequence of differential cell positioning at relatively late preimplantation stages. Differences in Oct4 transcription factor kinetics between cells at the 4-8-cell stage are now shown to be predictive of future lineages, providing further evidence for much earlier initiation of cell fate decisions.
引用
收藏
页码：112 / 114
页数：4
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