Expression of MACC1-1 and c-Met in human prostatic cancer and their clinicopathological significance

被引:0
作者
Fan, Bo [1 ]
Xu, Songtao [2 ]
Jin, Xiaohua [1 ]
Ding, Li [1 ]
机构
[1] Soochow Univ, Changshu Hosp, Dept Urol, 1 Shu Yuan Rd, Changshu 215500, Jiangsu, Peoples R China
[2] Luohe Med Coll, Dept Clin, Luohe, Henan, Peoples R China
来源
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY | 2016年 / 9卷 / 04期
关键词
Prostatic cancer; metastasis-associated in colon cancer-1; immunohistochemisty; c-Met; survival; COLON-CANCER; COLORECTAL-CANCER; SIGNALING PATHWAY; GASTRIC-CANCER; GROWTH-FACTOR; METASTASIS; ANTIGEN; OVEREXPRESSION; PROLIFERATION; PROGRESSION;
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Objective: Metastasis-associated in colon cancer-1 (MACC-1) and c-Met are associated with tumorigenesis and progression. The aim of this study is to investigate the expression of MACC-1 and c-Met in human prostatic cancer (PCa) and explore their clinical and pathological significance. Methods: The expression of MACC-1 and c-Met protein were detected in 84 cases of human PCa and 20 cases of benign prostatic hyperplasia (BPH) tissues by the immunohistochemical method. Results: The positive expression level of MACC-1 was 56.0% in human PCa which was higher than that in BPH tissues (20.0%), P=0.004. The overexpression of MACC1 protein was correlated with tumor Gleason score, PSA and TNM stage (P=0.001, P=0.027 and P<0.001, respectively). The positive expression of c-Met was 64.3% in PCa, which was higher than that in BPH tissues (30%). P=0.005. The overexpression of c-Met protein was correlated with tumor Gleason score, PSA and TNM stage (P=0.020, P=0.037 and P<0.001, respectively). The log-rank test statistical analysis suggested that patients with overexpression MACC-1 or c-Met protein had shorter overall survival time, while patients with lower expression MACC-1 or c-Met protein had better survival. Conclusion: Overexpression of MACC-1 and c-Met are markedly correlated with tumor Gleason score, PSA and TNM stage. Detection of MACC-1 and c-Met may be helpful to evaluate prognosis and infiltrative capability of PCa. In PCa tissues, the expression of MACC-1 was positively correlated with the expression of c-Met protein (r=0.540, P<0.001).
引用
收藏
页码:4654 / 4660
页数:7
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