Disorder- and emotional context-specific neurofunctional alterations during inhibitory control in generalized anxiety and major depressive disorder

被引：24

作者：

Liu, Congcong ^{[1
]}

Dai, Jing ^{[1
,2
]}

Chen, Yuanshu ^{[1
]}

Qi, Ziyu ^{[1
]}

Xin, Fei ^{[1
]}

Zhuang, Qian ^{[1
]}

Zhou, Xinqi ^{[1
]}

Zhou, Feng ^{[1
]}

Luo, Lizhu ^{[1
,2
]}

Huang, Yulan ^{[3
]}

Wang, Jinyu ^{[3
]}

Zou, Zhili ^{[3
]}

Chen, Huafu ^{[1
]}

Kendrick, Keith M. ^{[1
]}

Zhou, Bo ^{[3
]}

Xu, Xiaolei ^{[1
]}

Becker, Benjamin ^{[1
]}

机构：

[1] Univ Elect Sci & Technol China, High Field Magnet Resonance Brain Imaging Key Lab, MOE Key Lab NeuroInformat, Clin Hosp Chengdu Brain Sci Inst, Chengdu 610054, Sichuan, Peoples R China

[2] Chengdu Mental Hlth Ctr, Chengdu 610036, Sichuan, Peoples R China

[3] Sichuan Acad Med Sci & Sichuan Prov Peoples Hosp, Dept Psychosomat Med, Chengdu 610072, Sichuan, Peoples R China

来源：

NEUROIMAGE-CLINICAL | 2021年 / 30卷

关键词：

Generalized anxiety disorder; Major depressive disorder; Biomarker; Emotion; Inhibitory control; DORSOLATERAL PREFRONTAL CORTEX; COGNITIVE CONTROL; NEGATIVE AFFECT; NEURAL BASIS; GO TASK; METAANALYSIS; STIMULATION; COMMON; MOOD; ABNORMALITIES;

D O I：

10.1016/j.nicl.2021.102661

中图分类号：

R445 [影像诊断学];

学科分类号：

100207 ;

摘要：

Major Depressive Disorder (MDD) and Generalized Anxiety Disorder (GAD) are highly debilitating and often comorbid disorders. The disorders exhibit partly overlapping dysregulations on the behavioral and neurofunctional level. The determination of disorder-specific behavioral and neurofunctional dysregulations may therefore promote neuro-mechanistic and diagnostic specificity. In order to determine disorder-specific alterations in the domain of emotion-cognition interactions the present study examined emotional context-specific inhibitory control in treatment-naive MDD (n = 37) and GAD (n = 35) patients and healthy controls (n = 35). On the behavioral level MDD but not GAD exhibited impaired inhibitory control irrespective of emotional context. On the neural level, MDD-specific attenuated recruitment of inferior/medial parietal, posterior frontal, and midcingulate regions during inhibitory control were found during the negative context. GAD exhibited a stronger engagement of the left dorsolateral prefrontal cortex relative to MDD. Overall the findings from the present study suggest disorder- and emotional context-specific behavioral and neurofunctional inhibitory control dysregulations in major depression and may point to a depression-specific neuropathological and diagnostic marker.

引用

页数：8