Palladium-Catalyzed Cross-Coupling of Arylboronic Acid and Benzonitriles Using DMSO as the Methylene Source

被引：20

作者：

Ai, Han-Jun ^{[1
]}

Qi, Xinxin ^{[1
]}

Peng, Jin-Bao ^{[1
]}

Ying, Jun ^{[1
]}

Wu, Xiao-Feng ^{[1
,2
]}

机构：

[1] Zhejiang Sci Tech Univ, Dept Chem, Xiasha Campus, Hangzhou 310018, Peoples R China

[2] Univ Rostock, Leibniz Inst Katalyse eV, Albert Einstein Str 29a, D-18059 Rostock, Germany

来源：

ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 7卷 / 10期

关键词：

palladium; amides; DMSO; cross-coupling; methylene sources; METAL-FREE CONDITIONS; DIMETHYL-SULFOXIDE; CONVENIENT ACCESS; METHYLATION; IMIDAZOHETEROCYCLES; FORMYLATION; REAGENT; KETONES;

D O I：

10.1002/ajoc.201800502

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An interesting strategy on palladium-catalyzed cross-coupling of arylboronic acids and benzonitriles has been developed. In this approach, DMSO was utilized as the methylene source and reacted with benzamides (generated insitu from benzonitriles) to form an N-acyliminium cation, followed by palladium-catalyzed cross-coupling with phenylboronic acids to afford the final products. A variety of the desired products were obtained in moderate to excellent yield.

引用

页码：2045 / 2048

页数：4

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