Update on prevalence and mechanisms of resistance to linezolid, tigecycline and daptomycin in enterococci in Europe: Towards a common nomenclature

被引：188

作者：

Bender, Jennifer K. ^{[1
]}

Cattoir, Vincent ^{[2
,3
,4
,5
]}

Hegstad, Kristin ^{[6
,7
]}

Sadowy, Ewa ^{[8
]}

Coque, Teresa M. ^{[9
,10
]}

Westh, Henrik ^{[11
,12
]}

Hammerum, Anette M. ^{[13
]}

Schaffer, Kirsten ^{[14
]}

Burns, Karen ^{[15
,16
]}

Murchan, Stephen ^{[16
]}

Novais, Carla ^{[17
]}

Freitas, Ana R. ^{[17
]}

Peixe, Luisa ^{[17
]}

Del Grosso, Maria ^{[18
]}

Pantosti, Annalisa ^{[18
]}

Werner, Guido ^{[1
]}

机构：

[1] Robert Koch Inst, Div Nosocomial Pathogens & Antibiot Resistances, Dept Infect Dis, Wernigerode, Germany

[2] Univ Hosp Rennes, Dept Clin Microbiol, Rennes, France

[3] Univ Hosp Rennes, Natl Reference Ctr Enterococci, Rennes, France

[4] Univ Rennes, Med Sch, Rennes, France

[5] Univ Rennes, INSERM Unit, U1230, Rennes, France

[6] Univ Hosp North Norway, Dept Microbiol & Infect Control, Norwegian Natl Advisory Unit Detect Antimicrobial, Tromso, Norway

[7] Arctic Univ Norway, Univ Tromso, Fac Hlth Sci, Res Grp Host Microbe Interact,Dept Med Biol, Tromso, Norway

[8] Natl Med Inst, Dept Mol Microbiol, Warsaw, Poland

[9] Romany Cajal Univ Hosp, Dept Microbiol, Raman y Cajal Hlth Res Inst IRYCIS, Madrid, Spain

[10] Ctr Invest Biomed Red Epidemiol & Salud Publ CIBE, Madrid, Spain

[11] Univ Copenhagen, Inst Clin Med, Fac Hlth & Med Sci, Hvidovre, Denmark

[12] Hvidovre Univ Hosp, Dept Clin Microbiol, Hvidovre, Denmark

[13] Statens Serum Inst, Infect Dis Preparedness, Dept Bacteria Parasites & Fungi, Copenhagen S, Denmark

[14] St Vincents Univ Hosp, UCD Sch Med, Dept Clin Microbiol, Dublin, Ireland

[15] Royal Coll Surgeons Ireland, Beaumont Hosp, Dublin, Ireland

[16] Hlth Protect Surveillance Ctr, Dublin, Ireland

[17] Univ Porto, Fac Farm, Lab Microbiol, Dept Ciencias Biol,UCIBIO,REQUIMTE, Porto, Portugal

[18] Ist Super Sanita, Dept Infect Dis, Rome, Italy

来源：

DRUG RESISTANCE UPDATES | 2018年 / 40卷

关键词：

vanA; vanB; VRE; Linezolid; Tigecycline; Daptomycin; BLOOD-STREAM INFECTIONS; HIGH-DOSE DAPTOMYCIN; MULTIRESISTANCE GENE CFR; RIBOSOMAL S10 PROTEIN; MULTIDRUG EFFLUX PUMP; STAPHYLOCOCCUS-AUREUS; ANTIMICROBIAL SUSCEPTIBILITY; BACTERICIDAL ACTIVITY; 1ST REPORT; MOLECULAR EPIDEMIOLOGY;

D O I：

10.1016/j.drup.2018.10.002

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Vancomycin-resistant enterococci (VRE) are important nosocomial pathogens. Invasive VRE infections are difficult to treat since common therapeutic options including ampicillin and glycopeptides often fail. In vitro, most VRE remain susceptible to last-resort antibiotics such as linezolid, tigecycline and daptomycin. However, neither tigecycline nor linezolid act in a bactericidal manner, and daptomycin has proven activity only at high dosages licensed for treating enterococcal endocarditis. Despite these pharmacological and therapeutic limitations, reports on resistance to these last -resort drugs in VRE, and enterococci in general, have increased in recent years. In this review, we briefly recapitulate the current knowledge on the mode of action as well as the known and novel mechanisms of resistance and describe surveillance data on resistance to linezolid, tigecycline and daptomycin in enterococci. In addition, we also suggest a common nomenclature for designating enterococci and VRE with resistances to these important last-resort antibiotics.

引用

页码：25 / 39

页数：15

共 213 条

[71] Evaluation of Standard- and High-Dose Daptomycin versus Linezolid against Vancomycin-Resistant Enterococcus Isolates in an In Vitro Pharmacokinetic/Pharmacodynamic Model with Simulated Endocardial Vegetations [J].