Phosphorescent iridium(III) complex for efficient sensing of hypochlorite and imaging in living cells

被引：8
作者：
Liu, Jinsheng [1 ]
Shangguan, Mingqin [2 ]
Zeng, Xiaoyang [2 ]
Guo, Yingxiong [2 ]
Wang, Tao [3 ]
Hou, Linxi [2 ]
机构：
[1] Fujian Med Univ, Fujian Prov Hosp, Teaching Hosp, Fuzhou, Fujian, Peoples R China
[2] Fuzhou Univ, Coll Chem Engn, Xueyuan Rd 2, Fuzhou 350116, Peoples R China
[3] Fujian Prov Hosp, Pediat Dept, Fuzhou 350001, Fujian, Peoples R China
来源：
ANALYTICAL BIOCHEMISTRY | 2020年 / 592卷
基金：
中国国家自然科学基金;
关键词：
Phosphorescent probe; Hypochlorite; Iridium(III) complex; Cell imaging; 2-PHOTON FLUORESCENT-PROBE; ACID DETECTION; RATIOMETRIC DETECTION; WATER; MITOCHONDRIA; LYSOSOME; SELECTIVITY; DESIGN;
D O I：
10.1016/j.ab.2019.113573
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
In consideration of the strong oxidizing power of hypochlorite (ClO-), which could cleave C=N moiety, a cyclometalated iridium (III) complex (Ir-Ts) modified hydrazide group as the response unit was synthesized to sensitively and selectively detect ClO- under neutral condition. Upon addition of ClO-, a 21-fold emission enhancement at 574 nm was observed and phosphorescent product was formed due to the cleavage of C=N moiety. The probe Ir-Ts displayed rapid response ( < 15 s) and high selectivity toward ClO- with a low detection limit of 86 nM. More importantly, bioimaging of ClO- was further studied in living cells.
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页数：5
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