Interindividual variability of drug transporters: Impact on opioid treatment in chronic renal failure

被引：3
作者：
Ranzani, Guglielmina Nadia [1 ]
De Gregori, Simona
De Gregori, Manuela [1 ]
Regazzi, Mario
Govoni, Stefano
机构：
[1] Univ Pavia, Dept Genet & Microbiol, I-27100 Pavia, Italy
来源：
ACUTE AND CHRONIC PAIN: WHERE WE ARE AND WHERE WE HAVE TO GO | 2009年
关键词：
Transporters; Opioids; Chronic renal failure; Polymorphism; Dialysis; P-GLYCOPROTEIN; ORGANIC ANION; IN-VIVO; METABOLISM; EXPRESSION; PHARMACOKINETICS; POLYMORPHISMS; MORPHINE; DISPOSITION; LOPERAMIDE;
D O I：
10.1016/j.eujps.2009.07.010
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Some transmembrane transporters influence the absorption, the tissue distribution and the elimination of opioids, and their genetic variants may be an important factor in therapeutic efficacy and toxicity. Uptake and efflux transporters may facilitate or limit access of opioids to blood-brain barrier (BBB), modulating pain relief. As renal function is crucial in the metabolism and pharmacokinetic profile of any drug, renal failure and end-stage renal disease may alter drug disposition by affecting protein and tissue binding, and reducing systemic clearance of drugs. (C) 2009 European Federation of International Association for the Study of Pain Chapters. Published by Elsevier Ltd. All rights reserved.
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页码：21 / +
页数：3
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