Anti-fatigue activity of purified anthocyanins prepared from purple passion fruit (P. edulis Sim) epicarp in mice

被引：57
作者：
Hu, Min [1 ]
Du, Juan [1 ,2 ]
Du, Lianduo [1 ]
Luo, Qiushui [1 ,2 ]
Xiong, Jianhua [1 ,2 ]
机构：
[1] Jiangxi Agr Univ, Coll Food Sci & Engineer, Nanchang 330045, Jiangxi, Peoples R China
[2] Key Lab Agr Prod Proc & Qual Control Nanchang Cit, Nanchang 330045, Jiangxi, Peoples R China
来源：
JOURNAL OF FUNCTIONAL FOODS | 2020年 / 65卷
基金：
中国国家自然科学基金;
关键词：
Purple passion fruit epicarp; Anthocyanins; Anti-fatigue; Forced swimming test; SKELETAL-MUSCLE; INFLAMMATORY CYTOKINES; ANTIOXIDANT ACTIVITY; HEALTH-BENEFITS; POLYSACCHARIDE; PURIFICATION; RESVERATROL; JAPONICUS; RESPONSES; PEPTIDES;
D O I：
10.1016/j.jff.2019.103725
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Demands for anthocyanins are steadily growing due to their positive bioactivities in human health and food coloration. This study was performed to evaluate the characteristics of purified purple passion fruit epicarp anthocyanins (PFEA) as well as its anti-fatigue activity and underlying mechanisms in mice. The result showed that three major anthocyanins including cyanidin-3-O-glucoside, cyanidin-3-O-rutinoside and peonidin-3-O-glucoside were identified, and the total content of these anthocyanins was 710.40 mg/g in PFEA. PFEA significantly prolonged the weight-loaded forced swimming time, decreased lactate dehydrogenase (LDH), the blood lactate (BLA) and the blood urea nitrogen (BUN) levels, and increased the liver glycogen (LG) content. Meanwhile, PFEA could ameliorate fluctuates in oxidative stress biomarkers (MDA), antioxidant enzymes (SOD) and inflammatory cytokines (TNF-alpha, IL-1 beta, IL-6). Moreover, the mRNA expression of PGC-1 alpha and PPAR alpha in skeletal muscles were also up-regulated by PFEA treatment. In conclusion, these results showed that supplementing PFEA could relieve fatigue effects.
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页数：8
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