ADAMs: modulators of cell-cell and cell-matrix interactions

被引：329

作者：

White, JM ^{[1
]}

机构：

[1] Univ Virginia, Sch Med, Hlth Syst, Dept Cell Biol, Charlottesville, VA 22908 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2003年 / 15卷 / 05期

关键词：

D O I：

10.1016/j.ceb.2003.08.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

ADAMs contain adhesive and metalloprotease domains. As major ectodomain sheddases, they release a variety of cell-surface proteins, including growth factors, cytokines, cell adhesion molecules and receptors. ADAMs can also cleave and remodel components of the extracellular matrix. Hence, ADAMs are emerging as key modulators of cell-cell and cell-matrix interactions. Important questions, including if and how ADAM adhesive domains promote ADAM protease function, are currently being addressed.

引用

页码：598 / 606

页数：9

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