Motor sequence learning in patients with ideomotor apraxia: Effects of long-term training

被引:2
作者
Willms, Sarah [1 ]
Abel, Miriam [1 ]
Karni, Avi [2 ]
Gal, Carmit [2 ]
Doyon, Julien [3 ]
King, Bradley R. [4 ,5 ]
Classen, Joseph [6 ]
Rumpf, Jost-Julian [6 ]
Buccino, Giovanni [7 ,8 ]
Pellicano, Antonello [1 ]
Klann, Juliane [1 ,9 ]
Binkofski, Ferdinand [1 ,10 ]
机构
[1] Rhein Westfal TH Aachen, Med Fac, Dept Neurol, Div Clin & Cognit Sci, Aachen, Germany
[2] Univ Haifa, Dept Neurobiol, Haifa, Israel
[3] McGill Univ, McConnell Brain Imaging Ctr, Montreal, PQ, Canada
[4] Univ Utah, Dept Hlth & Kinesiol, Salt Lake City, UT USA
[5] Katholieke Univ Leuven, Dept Movement Sci, Leuven, Belgium
[6] Univ Leipzig, Dept Neurol, Leipzig, Germany
[7] IRCCS, Div Neurosci, Milan, Italy
[8] Univ Vita Salute San Raffaele, Milan, Italy
[9] SRH Univ Appl Hlth Sci, Campus Heidelberg, Heidelberg, Germany
[10] Res Ctr Julich GmbH, Inst Med & Neurosci INM 4, Julich, Germany
关键词
Apraxia; chronic stroke; motor sequence learning; long term training; motor memory; BRAIN PLASTICITY; CONSOLIDATION; SKILL; IMITATION; ACQUISITION; PANTOMIME; RETENTION; GESTURES; TIME;
D O I
10.1016/j.neuropsychologia.2021.107921
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Recent studies show that limb apraxia is a quite frequent, yet often underdiagnosed, higher motor impairment following stroke. Because it adversely affects every-day life and personal independence, successful rehabilitation of apraxia is essential for personal well-being. Nevertheless, evidence of long-term efficacy of training schemes and generalization to untrained actions is still scarce. One possible reason for the tendency of this neurological disorder to persist may be a deficit in planning, conceptualisation and storage of complex motor acts. This pilot study aims at investigating explicit motor learning in apractic stroke patients. In particular, we addressed the ability of apractic patients to learn and to retain new explicit sequential finger movements across 10 training sessions over a 3-week interval. Nine stroke patients with ideomotor apraxia in its chronic stage participated in a multi-session training regimen and were included in data analyses. Patients performed an explicit finger sequence learning task (MSLT - motor sequence learning task), which is a well-established paradigm to investigate motor learning and memory processes. Patients improved task performance in terms of speed and accuracy across sessions. Specifically, they showed a noticeable reduction in the mean time needed to perform a correct sequence and the number of erroneous sequences. We found also a trend for improved performance at the Goldenberg apraxia test protocol: "imitation of meaningless hand and finger gestures" relative to when assessed before the MSLT training. Patients with ideomotor apraxia demonstrated the ability to acquire and maintain a novel sequence of movements; and, this training was associated with hints towards improvement of apraxia symptoms.
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页数:9
相关论文
共 61 条
[1]   Hippocampus and Striatum: Dynamics and Interaction During Acquisition and Sleep-Related Motor Sequence Memory Consolidation [J].
Albouy, Genevieve ;
King, Bradley R. ;
Maquet, Pierre ;
Doyon, Julien .
HIPPOCAMPUS, 2013, 23 (11) :985-1004
[2]   Anodal tDCS over left parietal cortex expedites recovery from stroke-induced apraxic imitation deficits: a pilot study [J].
Ant, Jana M. ;
Niessen, Eva ;
Achilles, Elisabeth I. S. ;
Saliger, Jochen ;
Karbe, Hans ;
Weiss, Peter H. ;
Fink, Gereon R. .
NEUROLOGICAL RESEARCH AND PRACTICE, 2019, 1 (01)
[3]   Sequence learning is driven by improvements in motor planning [J].
Ariani, Giacomo ;
Diedrichsen, Jorn .
JOURNAL OF NEUROPHYSIOLOGY, 2019, 121 (06) :2088-2100
[4]   Apraxias [J].
Binkofski F. ;
Fink G. .
Der Nervenarzt, 2005, 76 (4) :493-512
[5]  
Binkofski F., 2013, FACHZEITSCHRIFT NOT, V5, P24
[6]  
Binkofski FA., 2020, NEUROLOGIE UP2DATE, V3, P275
[7]   Two action systems in the human brain [J].
Binkofski, Ferdinand ;
Buxbhaum, Laurel J. .
BRAIN AND LANGUAGE, 2013, 127 (02) :222-229
[8]   Sequence Skill Acquisition and Off-Line Learning in Normal Aging [J].
Brown, Rachel M. ;
Robertson, Edwin M. ;
Press, Daniel Z. .
PLOS ONE, 2009, 4 (08)
[9]   Treatment of limb apraxia - Moving forward to improved action [J].
Buxbaum, Laurel J. ;
Haaland, Kathleen Y. ;
Hallett, Mark ;
Wheaton, Lewis ;
Heilman, Kenneth M. ;
Rodriguez, Amy ;
Rothi, Leslie J. Gonzalez .
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION, 2008, 87 (02) :149-161
[10]  
Buxbaum Laurel J, 2018, Handb Clin Neurol, V151, P349, DOI 10.1016/B978-0-444-63622-5.00017-6