Homocysteine in Vascular Behcet Disease A Meta-Analysis

被引:30
作者
La Regina, Micaela [1 ]
Orlandini, Francesco [1 ]
Prisco, Domenico [2 ]
Dentali, Francesco [3 ]
机构
[1] Ligurian E Hosp, Dept Internal Med, I-19124 La Spezia, Italy
[2] Univ Florence, Dept Med & Surg Care, I-50121 Florence, Italy
[3] Univ Insubria, Dept Clin Med, Varese, Italy
关键词
homocysteine; thrombosis; Behcet disease; metaanalysis; vascular manifestations; THROMBOPHILIC RISK-FACTORS; FACTOR-V-LEIDEN; VENOUS THROMBOSIS; MYOCARDIAL-INFARCTION; ASSOCIATION; HYPERHOMOCYSTEINAEMIA; THROMBOEMBOLISM; INVOLVEMENT; EXPRESSION; PREVENTION;
D O I
10.1161/ATVBAHA.110.207068
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective-Behcet disease (BD) is a vasculitis of unknown etiology, characterized by oral or genital aphtosis and uveitis. Homocysteine (hcy) is an independent risk factor for venous and arterial thrombosis. The association between hyperhomocysteinemia and thrombosis has been investigated in some studies in BD patients. However, information on this association is based only on the results of small studies with conflicting results. To overcome such limitations, we performed a metaanalysis comparing the plasma levels of hcy in BD patients with and without history of thrombosis. Methods and Results-We searched for all published studies using the Medline and Embase databases. Two reviewers performed study selection independently. Studies were included if hcy was measured in adult BD patients with and without thrombosis. Two reviewers independently extracted data on study and population characteristics. The mean value of hcy in BDpatients and the presence of hyperhomocysteinemia in patients with and without thrombosis were collected. Association between thrombosis and hyperhomocysteinemia, and the mean difference of hcy levels in BD patients with and without thrombosis were calculated. Sixteen studies, for a total of 979 patients, were included. Hyperhomocysteinemia was more prevalent in patients with thrombosis than in those without (odds ratio 3.14; 95% CI 1.26 to 7.80) Mean levels of hcy were significantly higher in patients with thrombosis in comparison with patients without (mean difference 3.30 mu mol/L; 95% CI 2.09 to 4.51). Conclusion-Our results suggest that hyperhomocysteinemia may be considered to be associated with thrombosis in BD patients. (Arterioscler Thromb Vasc Biol. 2010; 30: 2067-2074.)
引用
收藏
页码:2067 / U368
页数:10
相关论文
共 50 条
  • [21] Homocysteine (HCY) levels in patients with atrial fibrillation (AF): A meta-analysis
    Dong, Xin-Jiang
    Wang, Bei-Bei
    Hou, Fei-Fei
    Chen, Kai-Peng
    Zhou, Hui-Dong
    Guo, Jing-Wei
    Sun, Xun
    Liu, Xiao-Li
    Chen, Li-Juan
    INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, 2021, 75 (12)
  • [22] Relationship between total plasma homocysteine and the risk of aneurysms - a meta-analysis
    Zhang, Hanji
    Yin, Dexin
    Zhao, Yue
    Li, Yezhou
    Yao, Dejiang
    Sun, Dajun
    VASA-EUROPEAN JOURNAL OF VASCULAR MEDICINE, 2021, 50 (02) : 110 - 115
  • [23] Intercellular adhesion molecule-1 polymorphisms in patients with Behcet disease: A meta-analysis
    Zou, Jun
    Guan, Jian-Long
    MODERN RHEUMATOLOGY, 2014, 24 (03) : 481 - 486
  • [24] Ocular manifestations of Behcet's disease in children and adults: a systematic review and meta-analysis
    Turk, M. A.
    Hayworth, J. L.
    Nevskaya, T.
    Pope, J. E.
    CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 2021, 39 (05) : S94 - S101
  • [25] Plasma homocysteine, folate and vitamin B12 levels in Parkinson's disease in China: A meta-analysis
    Dong, Bao
    Wu, Rongrong
    CLINICAL NEUROLOGY AND NEUROSURGERY, 2020, 188
  • [26] Serum homocysteine level in Behcet's disease
    Çalikoglu, E
    Öztas, M
    Sengül, N
    Adam, B
    Gürer, MA
    HAEMATOLOGIA, 2002, 32 (03) : 219 - 224
  • [27] Homocysteine as a predictor and prognostic marker of atherosclerotic cardiovascular disease: a systematic review and meta-analysis
    Habib, S. S.
    Al-Khlaiwi, T.
    Almushawah, A.
    Alsomali, A.
    Habib, S. A.
    EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 2023, 27 (18) : 8598 - 8608
  • [28] Sex Differences in the Level of Homocysteine in Alzheimer's Disease and Parkinson's Disease Patients: A Meta-Analysis
    Nguyen, V. Phu
    Collins, Andrila E.
    Hickey, Jordan P.
    Pfeifer, Julia A.
    Kalisch, Bettina E.
    BRAIN SCIENCES, 2023, 13 (01)
  • [29] Association between Homocysteine Levels and Psoriasis: A Meta-Analysis
    Kim, Jung Eun
    Lee, Ho Jung
    Lee, Jong Suk
    Whang, Kyu Uang
    Park, Young Lip
    Lee, Sung Yul
    Kim, Hyun Jung
    ANNALS OF DERMATOLOGY, 2019, 31 (04) : 378 - 386
  • [30] Homocysteine and the Mortality of Critically Ill Patients: A Meta-Analysis
    Yuan, Fawei
    Zheng, Kun
    HORMONE AND METABOLIC RESEARCH, 2022, 54 (09) : 593 - 603