Molecular phylogeny within type I cytokines and their cognate receptors

被引：202

作者：

Boulay, JL ^{[1
]}

O'Shea, JJ

Paul, WE

机构：

[1] Univ Basel Hosp, Dept Res, CH-4031 Basel, Switzerland

[2] NIAMSD, Mol Immunol & Inflammat Branch, NIH, Bethesda, MD 20892 USA

[3] NIAID, Immunol Lab, NIH, Bethesda, MD 20892 USA

来源：

IMMUNITY | 2003年 / 19卷 / 02期

关键词：

D O I：

10.1016/S1074-7613(03)00211-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Type I helical cytokines are ligands for receptors structurally related by a common sequence signature. Here we analyze the 27 ligands and 34 human type I cytokine receptor encoded by the human genome. We compare these to ligands and receptors found in mouse and insects. We describe their structural relatedness to one another and discuss the evolution of these gene families.

引用

页码：159 / 163

页数：5

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