A novel porous aspirin-loaded (GO/CTS-HA)n nanocomposite films: Synthesis and multifunction for bone tissue engineering

被引：29

作者：

Ji, Mingxiang ^{[1
]}

Li, Han ^{[2
]}

Guo, Hailin ^{[1
]}

Xie, Anjian ^{[1
]}

Wang, Shaohua ^{[1
]}

Huang, Fangzhi ^{[1
]}

Li, Shikuo ^{[1
]}

Shen, Yuhua ^{[1
]}

He, Jiacai ^{[2
]}

机构：

[1] Anhui Univ, Collaborat Innovat Ctr Modern Bio Manufacture, Sch Chem & Chem Engn, Hefei 230601, Peoples R China

[2] Anhui Med Univ, Stomatol Hosp & Coll, Key Lab Oral Dis Res Anhui Prov, Hefei 230032, Peoples R China

来源：

CARBOHYDRATE POLYMERS | 2016年 / 153卷

关键词：

Graphene oxide/chitosan-hydroxyapatite; Porous nanocomposite film; Layer-by-layer assembly technology; Biomimetic mineralization; Bone tissue engineering; BY-LAYER FILMS; GRAPHENE OXIDE; OSTEOGENIC DIFFERENTIATION; GELATIN NANOPARTICLES; NANO-HYDROXYAPATITE; STEM-CELLS; IN-VITRO; CHITOSAN; TITANIUM; IMMOBILIZATION;

D O I：

10.1016/j.carbpol.2016.07.078

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A novel porous graphene oxide (GO)/chitosan (CTS)-hydroxyapatite (HA) nanocomposite film was successfully prepared for the first time by combining layer-by-layer (LBL) assembly technology with biomimetic mineralization method. The LBL technology was used to control the thickness of film as well as induce the biomimetic mineralization of biocompatible HA. The obtained (GOICTS-HA)(n) film provided ideal platform for the proliferation of mouse mesenchymal stem cells (mMSCs). The pore size in the film is about 300 nm, and the porous architecture made the film have high aspirin loading efficiency. Also the accumulated loading dosage could be adjusted by the film thickness, and the sustained release of aspirin could ensure well anti-inflammatory effect. The above advantages may alleviate the pain of patients and give the better environment for bone regeneration. This multifunctional aspirin-loaded (GOICTS-HA)(n) film provided an inspiration for the synthesis of novel porous inorganic/biomacromolecule nanocomposite films as the biocoatings applied in bone tissue engineering. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：124 / 132

页数：9

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