Expedient synthesis of tetrahydroquinoline-3-spirohydantoin derivatives via the Lewis acid-catalyzed tert-amino effect reaction

被引：26

作者：

Briones, John F. ^{[1
,2
]}

Basarab, Gregory S. ^{[1
,3
]}

机构：

[1] AstraZeneca R&D Boston, Infect Innovat Med, 35 Gatehouse Dr, Waltham, MA 02451 USA

[2] Moderna Therapeut, 200 Technol Sq, Cambridge, MA 02139 USA

[3] Univ Cape Town, Dept Chem, Drug Discovery & Dev Ctr, ZA-7700 Rondebosch, South Africa

来源：

CHEMICAL COMMUNICATIONS | 2016年 / 52卷 / 55期

关键词：

C-H FUNCTIONALIZATION; SPIROOXINDOLE TETRAHYDROQUINOLINES; 1,5-HYDRIDE TRANSFER/CYCLIZATION; SPIROHYDANTOINS; CLOSURE; AGENT;

D O I：

10.1039/c6cc03600g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Magnesium triflate was found to effectively catalyze the tert-amino effect reaction (T-reaction) involving ethyl 3-(2-(dialkylamino)phenyl)-2-nitroacrylates leading to tetrahydroquinoline nitroester derivatives. These compounds can be readily transformed to the corresponding valuable spirohydantoin derivatives.

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收藏

页码：8541 / 8544

页数：4

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