Immunolocalization of β-catenin in pleomorphic adenomas and carcinomas ex-pleomorphic adenomas of salivary glands

被引：10

作者：

Genelhu, Mcirisci C. L. S.

Gobbi, Helenice

Arantes, Diele C. B.

Cardoso, Sergio V.

Cassali, Geovanni D.

机构：

[1] Inst Biol Sci, Lab Comparat Pathol, Minas Gerais, Brazil

[2] Univ Fed Minas Gerais, Sch Med, Dept Anat Pathol & Forens Med, Minas Gerais, Brazil

[3] Paiva Univ Ctr, Belo Horizonte, MG, Brazil

[4] Univ Estadual Montes Claros, Dept Dent, Oral Diagnosis Div, Uberlandia, MG, Brazil

[5] Univ Fed Uberlandia, Sch Dent, Oral Pathol Lab, Uberlandia, MG, Brazil

[6] Vale Rio Doce Univ, Immunol Res Lab, Minas Gerais, Brazil

来源：

APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY | 2007年 / 15卷 / 03期

关键词：

beta-catenin; pleomorphic adenoma; carcinoma; Salivary gland; immunohistochemistry;

D O I：

10.1097/01.pai.0000213123.04215.95

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

beta-catenin plays a central role in cadherin/catenin cell-cell adhesion complex and is involved in cell signaling pathway. Change in beta-caterlin distribution has been associated with several human cancers including salivary gland tumors. We studied the irnmunolocalization of beta-catenin in a series of pleornorphic adenomas (PA) and carcinomas ex-pleomorphic adenomas (Ca ex-PA). Ten samples of PA and ten of Ca ex-PA were evaluated by immunohistochemistry using streptavidin-biotin-peroxidase technique and a monoclonal antibody against beta-catenin (E - 5). Cell nierinbrane/cytoplasmic staining of beta-catenin was observed in normal gland parenchyma, PA, and in well-differentiated Ca ex-PA. Cytoplasmic/nuclear beta-catenin staining was observed in poorly differentiated carcinomas and, interestingly. in one case of PA. Our data showed decreased cell membrane beta-catenin expression in higher-grade tumors suggesting that beta-catenin may play an important role in histolovic differentiation and transition to malignant phenotype of Ca ex-PA.

引用

页码：273 / 278

页数：6

共 57 条

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