Post-transfusion purpura (PTP) and disseminated intravascular coagulation (DIC)

被引：5

作者：

Welling, KL

Taaning, E

Lund, BV

Rosenkvist, J

Heslet, L

机构：

[1] Univ Copenhagen, Dept Intens Care, Copenhagen, Denmark

[2] Univ Copenhagen, Rigshosp, Dept Clin Immunol, DK-2100 Copenhagen, Denmark

[3] Univ Copenhagen, Dept Clin Immunol, Herlev Hosp, Copenhagen, Denmark

来源：

EUROPEAN JOURNAL OF HAEMATOLOGY | 2003年 / 71卷 / 01期

关键词：

DIC; post-transfusion purpura; pan-reactive platelet antibodies; transfusion reaction; HPA-1a (Zw(a)) antibodies; thrombocytopenia; platelet alloimmunisation; plasma exchange;

D O I：

10.1034/j.1600-0609.2003.00092.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 47-yr-old female with acute pancreatitis received four units of fresh frozen plasma because of subtle signs of disseminated intravascular coagulation (DIC). Seven days later, she developed severe thrombocytopenia. Serological studies demonstrated antibodies against HPA-1a together with pan-reactive antibodies against platelet glycoproteins (GPIIb-IIIa, GPIb-IX and GPIa-IIa), which was consistent with the diagnosis of PTP. The patient was treated with platelet transfusions, corticosteroids and intravenous immunoglobulin (IVIG) without permanent beneficial effect. After treatment with plasma exchange the platelet count increased to normal values.

引用

页码：68 / 71

页数：4

共 17 条

[1] Posttransfusion purpura secondary to an alloantibody reactive with HPA-5a (Brb) [J].