Adhesion and Migration, the Diverse Functions of the Laminin α3 Subunit

被引：34

作者：

Hamill, Kevin J. ^{[1
]}

Paller, Amy S. ^{[1
,2
]}

Jones, Jonathan C. R. ^{[2
,3
]}

机构：

[1] Northwestern Univ, Feinberg Sch Med, Dept Cell & Mol Biol, Chicago, IL 60611 USA

[2] Northwestern Univ, Feinberg Sch Med, Dept Dermatol, Chicago, IL 60611 USA

[3] Northwestern Univ, Feinberg Sch Med, Dept Pediat, Chicago, IL 60611 USA

来源：

DERMATOLOGIC CLINICS | 2010年 / 28卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Basement membrane; Cell adhesion; Cell migration; Laminins; BULLOUS-PEMPHIGOID ANTIGEN; N-TERMINAL DOMAINS; BETA-4; INTEGRIN; ALPHA-6-BETA-4; DIRECTIONAL MIGRATION; EXTRACELLULAR-MATRIX; PROTEOLYTIC FRAGMENT; CELLULAR ADHESION; EPITHELIAL-CELLS; FOCAL ADHESIONS;

D O I：

10.1016/j.det.2009.10.009

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The laminins are a secreted family of heterotrimeric molecules essential for basement membrane formation, structure, and function. It is now well established that the alpha 3 subunit of laminins-332, -321, and -311 plays an important role in mediating epidermal-dermal integrity and is essential for the skin to withstand mechanical stresses. These laminins also regulate cell migration and mechanosignal transduction. This article provides an overview of the gene, transcripts, and protein structures of laminin alpha 3. Also discussed are the proposed functions for the alpha 3 subunit-containing laminins.

引用

页码：79 / +

页数：10

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