Association of polymorphism in alcohol dehydrogenase and interaction with other genetic risk factors with alcoholic liver cirrhosis

被引：24
作者：
Khan, Anwar Jamal [1 ]
Husain, Qayyum [2 ]
Choudhuri, Gourdas [3 ]
Parmar, Devendra [1 ]
机构：
[1] CSIR, Indian Inst Toxicol Res, Div Dev Toxicol, Lucknow 226001, Uttar Pradesh, India
[2] Aligarh Muslim Univ, Dept Biochem, Fac Life Sci, Aligarh 202002, Uttar Pradesh, India
[3] Sanjay Gandhi Postgrad Inst Med Sci, Dept Gastroenterol, Lucknow 226014, Uttar Pradesh, India
来源：
DRUG AND ALCOHOL DEPENDENCE | 2010年 / 109卷 / 1-3期
关键词：
Alcoholic liver cirrhosis; Alcohol dehydrogenase; Polymorphism; Risk; Interaction; GLUTATHIONE-S-TRANSFERASES; FRAGMENT-LENGTH-POLYMORPHISM; METABOLIZING ENZYMES; CHRONIC-PANCREATITIS; CHINESE PATIENTS; ORGAN DAMAGE; DISEASE; SUSCEPTIBILITY; GENOTYPES; P4502E1;
D O I：
10.1016/j.drugalcdep.2010.01.010
中图分类号：
R194 [卫生标准、卫生检查、医药管理];
学科分类号：
摘要：
The association of polymorphism of alcohol dehydrogenase (ADH) and its interaction with genes involved in the generation and detoxification of free radicals such as cytochrome P4502E1 (CYP2E1) and glutathione S-transferases M1 (GSTM1) were studied with alcoholic liver cirrhosis. The study included 175 alcoholic cirrhotic patients, 140 non-alcoholic cirrhotic patients, 255 non-alcoholic controls and 140 alcoholic controls. Our data revealed that the ADH1C*1/*1 genotype exhibited significant association with alcoholic liver cirrhosis while ADH1B genotypes did not show any significant association. A much higher risk to alcoholic liver cirrhosis was observed in patients carrying a combination of wild genotypes of ADH1C (ADH1C1/*1) and variant genotype of ADH1B (ADH1B*2/.2) or CYP2E1 (CYP2E1*5B) or null genotype of GSTM1. Our data suggest a role for the interaction amongst the genes involved in metabolizing alcohol and in generating and detoxifying free radicals with susceptibility to alcoholic liver cirrhosis. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：190 / 197
页数：8
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