[1] Univ Manchester, Fac Life Sci, Manchester, Lancs, England
[2] Univ Manchester, Fac Engn & Phys Sci, Manchester, Lancs, England
[3] Pfizer, Neusentis, Worldwide Res & Dev, Cambridge CB21 6GS, England
[4] Univ Manchester, Canc Res UK Manchester Inst, Manchester, Lancs, England
[5] Univ Manchester, Manchester Inst Biotechnol, Manchester, Lancs, England