Short-term Therapy with Celecoxib and Lansoprazole Modulates Th1/Th2 Immune Response in Human Gastric Mucosa

被引:14
作者
Larussa, Tiziana [1 ]
Suraci, Evelina [1 ]
Leone, Isabella [1 ]
Nazionale, Immacolata [1 ]
Abenavoli, Ludovico [1 ]
Galasso, Olimpio [2 ]
Amorosi, Andrea [1 ]
Imeneo, Maria [1 ]
Luzza, Francesco [1 ]
机构
[1] Univ Catanzaro Magna Graecia, Dipartimento Med Sperimentale & Clin, I-88100 Catanzaro, Italy
[2] Univ Catanzaro Magna Graecia, Dipartimento Sci Med, I-88100 Catanzaro, Italy
关键词
Celecoxib; COX-2; H; pylori; Lansoprazole; T helper 1; T helper 2; PROTON PUMP INHIBITOR; HELICOBACTER-PYLORI INFECTION; ENDOTHELIAL-CELLS; CORPUS GASTRITIS; CYCLOOXYGENASE-2; EXPRESSION; CANCER; OMEPRAZOLE; ANTRUM; SOMATOSTATIN;
D O I
10.1111/j.1523-5378.2010.00796.x
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background: Selective cyclooxygenase-2 (COX-2) inhibitors and proton pump inhibitors may exert immune-mediated effects in human gastric mucosa. T-cell immune response plays a role in Helicobacter pylori-induced pathogenesis. This study evaluated effects of celecoxib and lansoprazole on T-helper (Th) 1 and Th2 immune response in human gastric mucosa. Methods: Dyspeptic patients with or without osteoarticular pain were given one of the following 4-week therapies: celecoxib 200 mg, celecoxib 200 mg plus lansoprazole 30 mg, and lansoprazole 30 mg daily. Expression of COX-2, T-bet, and pSTAT6 and production of prostaglandin E(2) (PGE(2)), interferon (IFN)-gamma, and interleukin (IL)-4 were determined in gastric biopsies before and after therapy. Histology was evaluated. Results: Cyclooxygenase-2 expression and PGE(2) production was higher, and Th1 signaling pathway was predominant in H. pylori-infected vs. uninfected patients. T-bet expression and IFN-gamma production increased, while STAT6 activation and IL-4 production decreased following therapy with celecoxib and celecoxib plus lansoprazole, respectively. Th1 and Th2 signaling pathways down-regulated after therapy with lansoprazole, and this was associated with an improvement of gastritis. Effect of therapy was not affected by H. pylori status. Conclusion: Celecoxib and lansoprazole modulate Th1/Th2 immune response in human gastric mucosa. The use of these drugs may interfere with long-term course of gastritis.
引用
收藏
页码:449 / 459
页数:11
相关论文
共 50 条
[41]   Pan-cancer analysis identifies LMNB1 as a target to redress Th1/Th2 imbalance and enhance PARP inhibitor response in human cancers [J].
Qin, Haixiang ;
Lu, Yingqiang ;
Du, Lin ;
Shi, Jingyan ;
Yin, Haoli ;
Jiang, Bo ;
Chen, Wei ;
Diao, Wenli ;
Ding, Meng ;
Cao, Wenmin ;
Qiu, Xuefeng ;
Zhao, Xiaozhi ;
Guo, Hongqian .
CANCER CELL INTERNATIONAL, 2022, 22 (01)
[42]   Golgi Phosphoprotein 2 Down-regulates the Th1 Response in Human Gastric Cancer Cells by Suppressing IL-12A [J].
Tang, Qing-Feng ;
Ji, Qing ;
Tang, Yu ;
Hu, Song-Jiao ;
Bao, Yi-Jie ;
Peng, Wen ;
Yin, Pei-Hao .
ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, 2013, 14 (10) :5747-5751
[43]   5-Aminolevulinic Acid-Mediated Sonodynamic Therapy Alleviates Atherosclerosis via Enhancing Efferocytosis and Facilitating a Shift in the Th1/Th2 Balance Toward Th2 Polarization [J].
Yang, Yang ;
Liu, Yuanyuan ;
Chen, Xi ;
Gong, Jie ;
Huang, Zhen ;
Wang, Wei ;
Shi, Yuanqi ;
Wang, Yu ;
Yao, Jianting ;
Shen, Zhaoqian ;
Tian, Zhen ;
Jin, Hong ;
Tian, Ye .
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2018, 47 (01) :83-96
[44]   Astragalus membranaceus modulates Th1/2 immune balance and activates PPARγ in a murine asthma model [J].
Chen, Shih-Ming ;
Tsai, Yau-Sheng ;
Lee, Su-Wen ;
Liu, Ya-Hui ;
Liao, Shuen-Kuei ;
Chang, Wen-Wei ;
Tsai, Pei-Jane .
BIOCHEMISTRY AND CELL BIOLOGY, 2014, 92 (05) :397-405
[45]   Th1 immune response to H. pylori infection varies according to the age of the patients and influences the gastric inflammatory patterns [J].
de Melo, Fabricio Freire ;
Rocha, Gifone Aguiar ;
Camargos Rocha, Andreia Maria ;
Teixeira, Kadima Nayara ;
Souza Pietra Pedroso, Silvia Helena ;
Pereira Junior, Joao Bosco ;
Fonseca de Castro, Lucia Porto ;
Demas Alvares Cabral, Monica Maria ;
Carvalho, Simone Diniz ;
Souto Bittencourt, Paulo Fernando ;
de Oliveira, Celso Afonso ;
de Magalhaes Queiroz, Dulciene Maria .
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY, 2014, 304 (3-4) :300-306
[46]   Enhanced activation of cyclooxygenase-2 downregulates Th1 signaling pathway in Helicobacter pylori-infected human gastric mucosa [J].
Pellicano, Antonia ;
Imeneo, Maria ;
Leone, Isabella ;
Larussa, Tiziana ;
Luzza, Francesco .
HELICOBACTER, 2007, 12 (03) :193-199
[47]   Human immune responses to Plasmodium falciparum infection: molecular evidence for a suboptimal THαβ and TH17 bias over ideal and effective traditional TH1 immune response [J].
Hu, Wan-Chung .
MALARIA JOURNAL, 2013, 12
[48]   Distinct Effects of Anti-Tumor Necrosis Factor Combined Therapy on TH1/TH2 Balance in Rheumatoid Arthritis Patients [J].
Herman, S. ;
Zurgil, N. ;
Machlav, S. ;
Shinberg, A. ;
Langevitz, P. ;
Ehrenfeld, M. ;
Deutsch, M. .
CLINICAL AND VACCINE IMMUNOLOGY, 2011, 18 (07) :1077-1082
[49]   Interleukin-12 drives the Th1 signaling pathway in Helicobacter pylori-infected human gastric mucosa [J].
Pellicano, Antonia ;
Sebkova, Ladislava ;
Monteleone, Giovanni ;
Guarnieri, Giovanni ;
Imeneo, Maria ;
Pallone, Francesco ;
Luzza, Francesco .
INFECTION AND IMMUNITY, 2007, 75 (04) :1738-1744
[50]   MERS-CoV infection is associated with downregulation of genes encoding Th1 and Th2 cytokines/chemokines and elevated inflammatory innate immune response in the lower respiratory tract [J].
Alosaimi, Bandar ;
Hamed, Maaweya E. ;
Naeem, Asif ;
Alsharef, Ali A. ;
AlQahtani, Saeed Y. ;
AlDosari, Kamel M. ;
Alamri, Aref A. ;
Al-Eisa, Kholoud ;
Khojah, Taghreed ;
Assiri, Abdullah M. ;
Enani, Mushira A. .
CYTOKINE, 2020, 126