Conformal nanocarbon coating of alumina nanocrystals for biosensing and bioimaging

被引：19

作者：

Aramesh, Morteza ^{[1
,2
,3
,4
]}

Tran, Phong A. ^{[5
,6
]}

Ostrikov, Kostya ^{[3
,5
,6
]}

Prawer, Steven ^{[4
]}

机构：

[1] ETH, Inst Biomed Engn, Lab Biosensors & Bioelect, CH-8092 Zurich, Switzerland

[2] QUT, Brisbane, Qld 4000, Australia

[3] CSIRO QUT Joint Sustainable Proc & Devices Lab, Lindfield, NSW 2070, Australia

[4] Univ Melbourne, Sch Phys, Melbourne, Vic 3010, Australia

[5] Queensland Univ Technol, Inst Hlth & Biomed Innovat, Sch Phys Chem & Mech Engn, Brisbane, Qld 4000, Australia

[6] Queensland Univ Technol, Inst Future Environm, Brisbane, Qld 4000, Australia

来源：

CARBON | 2017年 / 122卷

关键词：

Nanocarbon; Nanoparticles; Plasma growth; Structural properties; Biosensing and bioimaging; CARBON NANOTUBES; DRUG-DELIVERY; PLATFORM; DESIGNS; DNA;

D O I：

10.1016/j.carbon.2017.06.101

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A conformal coating technique with nanocarbon was developed to enhance the surface properties of alumina nanoparticles for bio-applications. The ultra-thin carbon layer induces new surface properties such as water dispersion, cytocompatibility and tuneable surface chemistry, while maintaining the optical properties of the core particle. The possibility of using these particles as agents for DNA sensing was demonstrated in a competitive assay. Additionally, the inherent fluorescence of the core alumina particles provided a unique platform for localization and monitoring of living organisms, allowing simultaneous cell monitoring and intra-cellular sensing. Nanoparticles were able to carry genes to the cells and release them in an environment where specific biomarkers were present. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：422 / 427

页数：6

共 16 条

[1] Surface charge effects in protein adsorption on nanodiamonds [J].