The association between ST18 gene polymorphism and severe pemphigus disease among Iranian population

被引:13
|
作者
Etesami, Ifa [1 ]
Seirafi, Hassan [1 ]
Ghandi, Narges [1 ]
Salmani, Hamzeh [2 ]
Arabpour, Maedeh [2 ]
Nasrollahzadeh, Ali [2 ]
Teimourpour, Amir [3 ]
Daneshpazhooh, Maryam [1 ]
Keramatipour, Mohammad [2 ]
机构
[1] Univ Tehran Med Sci, Dept Dermatol, Razi Hosp, Tehran, Iran
[2] Univ Tehran Med Sci, Dept Med Genet, Sch Med, Tehran, Iran
[3] Univ Tehran Med Sci, Dept Epidemiol & Biostat, Sch Publ Hlth, Tehran, Iran
关键词
pemphigus; severity; ST18; gene; VULGARIS;
D O I
10.1111/exd.13778
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Recently, ST18 polymorphism has played a role in increasing the risk of pemphigus among some populations such as Egyptian and Jewish. In addition, a variant within the ST18 promoter gene was shown to induce ST18 upregulation and cytokine secretion leading to keratinocyte susceptibility to anti-desmoglein antibodies. Thus, the present study aimed to assess the ST18 single nucleotide polymorphisms (SNP) relationship with pemphigus, disease severity and family history among Iranian population. A total of 111 pemphigus patients and 201 healthy controls were genotyped for three ST18 SNPs rs2304365, rs10504140 and rs4074067 by using TETRA-ARMS PCR method. The results indicated that risk allele A in rs2304365 was significantly higher in pemphigus patients, compared with the amount in the control group (OR = 2.43 CI = 1.49-3.975, P < 0.001). Thus, A allele represents a risk factor for pemphigus. Further, the patients carrying the risk allele had a more severe disease and a higher age of disease onset while no relationship was observed between the number of relapses and positive family history of pemphigus with the risk allele. Finally, dominant model was regarded as the strongest inheritance model for the associated risk. The present study confirmed the relationship between ST18 gene with pemphigus disease, a more severe disease, and a higher age of disease onset.
引用
收藏
页码:1395 / 1398
页数:4
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