GPR55 and the regulation of glucose homeostasis

被引：12
作者：
Tuduri, Eva [1 ,2 ]
Lopez, Miguel [1 ,2 ,3 ]
Dieguez, Carlos [1 ,2 ,3 ]
Nadal, Angel [4 ,5 ]
Nogueiras, Ruben [1 ,2 ,3 ]
机构：
[1] Univ Santiago de Compostela, CIMUS, Inst Invest Sanitarias IDIS, Avda Barcelona S-N, Santiago De Compostela 15782, A Coruna, Spain
[2] CIBER Fisiopatol Obesidad & Nutr CIBERobn, Santiago De Compostela 15706, Spain
[3] Univ Santiago Compostela, CIMUS, Dept Physiol, Avda Barcelona S-N, Santiago De Compostela 15782, Spain
[4] Univ Miguel Hemcindez, Inst Bioingn, Elche, Spain
[5] Univ Miguel Hemcindez, CIBER Diabet & Enfermedades Metab Asociadas CIBER, Elche, Spain
来源：
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2017年 / 88卷
关键词：
Endocannabinoids; Insulin; Islets; Obesity; L-ALPHA-LYSOPHOSPHATIDYLINOSITOL; RECEPTOR GPR55; CANNABINOID RECEPTOR; POTENTIAL ROLE; ISLETS; CELLS; IDENTIFICATION; MIGRATION; RELEASE; OBESITY;
D O I：
10.1016/j.biocel.2017.04.010
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Pathophysiological conditions such as obesity and type 2 diabetes (T2D) are reportedly associated to over activation of the endocannabinoid system (ECS). Therefore, modulation of the ECS offers potential therapeutic benefits on those diseases. GPR55, the receptor for L-a-lysophosphatidylinositol (LPI) that has also affinity for various cannabinoid ligands, is distributed at the central and peripheral level and it is involved in several physiological processes. This review summarizes the localization and role of GPR55 in tissues that are crucial for the regulation of glucose metabolism, and provides an update on its contribution in obesity and insulin resistance. Finally, the therapeutic potential of targeting the GPR55 receptor is also discussed.
引用
收藏
页码：204 / 207
页数：4
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