Structure and Cytotoxicity of Novel Lignans and Lignan Glycosides from the Aerial Parts of Larrea tridentata

被引：4

作者：

Yokosuka, Akihito ^{[1
]}

Iguchi, Tomoki ^{[1
]}

Jitsuno, Maki ^{[1
]}

Mimaki, Yoshihiro ^{[1
]}

机构：

[1] Tokyo Univ Pharm & Life Sci, Sch Pharm, 1432-1 Horinouchi, Hachioji, Tokyo 1920392, Japan

来源：

MOLECULES | 2021年 / 26卷 / 20期

关键词：

Larrea tridentata; Zygophyllaceae; aerial part; lignan; lignan glycoside; cytotoxicity; HL-60; cell; apoptosis; cell cycle; MEXICAN; PLANTS;

D O I：

10.3390/molecules26206186

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Previously, the authors conducted phytochemical investigations of the aerial parts of Larrea tridentata and reported triterpene glycosides and lignan derivatives. In continuation of the preceding studies, 17 lignans and lignan glycosides (1-17) were isolated, including seven new compounds (1-7). Herein, the structure of the new compounds was determined based on spectroscopic analysis and enzymatic hydrolysis. The cytotoxicity of 1-17 against HL-60 human promyelocytic leukemia cells was examined. Compounds 4-11 and 14-16 were cytotoxic to HL-60 cells, with IC50 values in the range of 2.7-17 mu M. Compound 6, which was the most cytotoxic among the unprecedented compounds, was shown to induce apoptotic cell death in HL-60 cells.</p>

引用

页数：14

共 23 条

[21] Lignans from Larrea tridentate (creosote bush) as fungal β-1,3-glucanase inhibitors [J].