Relationship Between Bariatric Surgery and Bone Mineral Density: a Meta-analysis

被引:58
作者
Ko, Byung-Joon [1 ]
Myung, Seung Kwon [2 ,3 ,4 ]
Cho, Kyung-Hwan [5 ]
Park, Yong Gyu [6 ]
Kim, Sin Gon [7 ]
Kim, Do Hoon [5 ]
Kim, Seon Mee [5 ]
机构
[1] Sungkyunkwan Univ, Sch Med, Kangbuk Samsung Hosp, Total Healthcare Ctr, Seoul 100742, South Korea
[2] Natl Canc Ctr, Res Inst, Mol Epidemiol Branch, Goyang 410769, South Korea
[3] Natl Canc Ctr, Dept Family Med, Goyang 410769, South Korea
[4] Natl Canc Ctr, Ctr Canc Prevent & Detect, Goyang 410769, South Korea
[5] Korea Univ, Coll Med, Dept Family Med, Seoul 136705, South Korea
[6] Catholic Univ Korea, Dept Biostat, Coll Med, Seoul 137701, South Korea
[7] Korea Univ, Coll Med, Dept Internal Med, Div Endocrinol & Metab, Seoul 136705, South Korea
关键词
Bariatric surgery; Bone density; DXA; Meta-analysis; Y GASTRIC BYPASS; VERTICAL BANDED GASTROPLASTY; WEIGHT-LOSS; LONG-TERM; CALCIUM-METABOLISM; BODY-COMPOSITION; WOMEN; DISEASE; LEPTIN; RESORPTION;
D O I
10.1007/s11695-015-1928-8
中图分类号
R61 [外科手术学];
学科分类号
摘要
A meta-analysis regarding bone loss after bariatric surgery, designed to compare surgical and nonsurgical groups, has not yet been performed. Therefore, we performed a meta-analysis to compare the differences between bariatric surgical groups and nonoperated controls with regard to bone mineral density. In March 2015, we performed a review of the literature using PubMed, EMBASE, and the Cochrane Library. The search focused on retrospective and prospective studies, including but not limited to randomized studies published in English. Among 1299 studies that were initially screened, ten met the selection criteria. For all types of bariatric surgery, bone density at the femoral neck was lower in the surgical group than in the nonsurgical control group (mean difference [MD] -0.05 g/cm(2); 95 % confidence interval [CI], -0.07 to -0.02; p = 0.001); no difference in bone density was found between the two groups at the lumbar spine (MD -0.01 g/cm(2); 95 % CI -0.07 to 0.05; p = 0.661). The analysis of Roux-en-Y gastric bypass showed similar results. Bone density at the femoral neck decreased after bariatric surgery, compared to that in nonsurgical controls, whereas bone density at the lumbar spine did not show a difference between groups. Further larger scale studies with comparative nonsurgical controls are warranted to overcome the heterogeneity among studies in this analysis and to add evidence of possible bone loss subsequent to bariatric surgical procedures.
引用
收藏
页码:1414 / 1421
页数:8
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