One-Pot Copper-Catalyzed Three-Component Reaction of Sulfonyl Azides, Alkynes, and Allylamines To Access 2,3-Dihydro-1H-imi-dazo[1,2-α]indoles

被引：7

作者：

Jin, Hongwei ^{[1
]}

Liu, Daohong ^{[1
]}

Zhou, Bingwei ^{[1
]}

Liu, Yunkui ^{[1
]}

机构：

[1] Zhejiang Univ Technol, Coll Chem Engn, Hangzhou 310014, Zhejiang, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2020年 / 52卷 / 09期

基金：

美国国家科学基金会;

关键词：

multicomponent reaction; copper catalysis; azide-alkyne cycloaddition; Ullmann coupling reaction; 2,3-dihydro-1H-imidazo[1,2-alpha]indoles; PEPTIDAL CHOLECYSTOKININ ANTAGONIST; MULTICOMPONENT REACTION SYNTHESIS; SIMPLE INDOLE ALKALOIDS; FACILE ACCESS; C-C; DIASTEREOSELECTIVE SYNTHESIS; 1,3-DIPOLAR CYCLOADDITION; ASPERGILLUS-ALLIACEUS; 4-COMPONENT REACTION; TANDEM SYNTHESIS;

D O I：

10.1055/s-0037-1610739

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A copper-catalyzed multicomponent reaction of sulfonyl azides, alkynes, and allylamines affording 2,3-dihydro-1H-imidazo-[1,2-alpha]indoles in moderate yields is reported. Four C-N bonds are constructed- by way of azide-alkyne cycloaddition (CuAAC) and double Ullmann-type coupling reactions in a one-pot process.

引用

页码：1417 / 1424

页数：8

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