Synthesis and anti-tuberculosis activity of 2,4-disubstituted quinolines

被引：0

作者：

Nayyart, Amit ^{[1
]}

Jain, Rahul ^{[1
]}

机构：

[1] Natl Inst Pharmaceut Educ & Res, Dept Med Chem, SAS Nagar 160062, India

来源：

INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2008年 / 47卷 / 01期

关键词：

tuberculosis; ring-substituted quinolines; drug-sensitive TB; drug-resistant TB; multi-drug resistant TB; extreme drug-resistant TB;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthesis and anti-tuberculosis activity of a new series of 2,4-disubstituted quinolines have been reported. The most Promising compounds have been found to exhibit 99% inhibition at 6.25 mu g/mL, against drug-sensitive M. tuberculosis H37Rv strain and >90% inhibition at 12.5 mu g/mL against isoniazid resistant TB strain.

引用

页码：117 / 128

页数：12

共 11 条

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