Synthesis of Spirobarbiturate Piperidin-2-one Derivatives via Cascade Aza-Michael/Michael Cyclization Reaction

被引：6

作者：

Liu, Xuehua ^{[1
]}

Wang, Chuanchuan ^{[2
]}

Wang, Xinlu ^{[1
]}

Ma, Zhiwei ^{[2
]}

Meng, Lei ^{[3
]}

Ding, Degang ^{[2
]}

Liu, Juntao ^{[2
]}

Chen, Yajing ^{[1
]}

机构：

[1] Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou 450001, Peoples R China

[2] Henan Univ Anim Husb & Econ, Fac Sci, Zhengzhou 450046, Peoples R China

[3] Henan Inst Vet Drug & Feed Control, Zhengzhou 450008, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 41卷 / 11期

关键词：

spirobarbiturate; piperidin-2-one; cascade reaction; Michael addition; BARBITURATE-BASED OLEFINS; ASYMMETRIC-SYNTHESIS; SPIROOXINDOLES; CYCLOADDITION; BEARING; DESIGN;

D O I：

10.6023/cjoc202105045

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly efficient cascade aza-Michael/intramolecular-Michael reaction employing barbiturate-derived alkenes and N-alkoxy acrylamides has been developed. The reaction proceeds smoothly under mild conditions and is amenable to gram scale synthesis, providing a practical tool in the synthesis of bioactive spirobarbiturate piperidin-2-ones molecules in moderate to good yields.

引用

页码：4450 / 4458

页数：9

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