Factors affecting the evaluation of biomonitoring data for human exposure assessment

被引：40

作者：

Calafat, Antonia M. ^{[1
]}

Needham, Larry L. ^{[1
]}

机构：

[1] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Sci Lab, Atlanta, GA 30341 USA

来源：

INTERNATIONAL JOURNAL OF ANDROLOGY | 2008年 / 31卷 / 02期

关键词：

amniotic fluid; meconium; stability;

D O I：

10.1111/j.1365-2605.2007.00826.x

中图分类号：

R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

摘要：

Measuring trace levels of multiple environmental chemicals in biological tissues (i.e., biomonitoring) with a high degree of accuracy and precision is possible thanks to sophisticated analytical chemistry techniques and highly trained laboratory personnel. Selection and validation of biomarkers of exposure are critical. We present examples of the use of biomonitoring in exposure assessment for non-persistent chemicals using phthalates as model compounds. We also discuss several factors relevant to interpreting and understanding biomonitoring data, including the impact of metabolism of the chemicals and matrix composition in the selection of biomarkers of exposure, as well as temporal stability considerations that may affect the biomarkers' concentrations.

引用

页码：139 / 143

页数：5

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