Phenotypic Diversity and Plasticity in Circulating Neutrophil Subpopulations in Cancer

被引：666

作者：

Sagiv, Jitka Y. ^{[1
]}

Michaeli, Janna ^{[2
]}

Assi, Simaan ^{[1
]}

Mishalian, Inbal ^{[2
]}

Kisos, Hen ^{[1
]}

Levy, Liran ^{[2
]}

Damti, Pazzit ^{[2
]}

Lumbroso, Delphine ^{[3
]}

Polyansky, Lola ^{[1
]}

Sionov, Ronit V. ^{[1
]}

Ariel, Amiram ^{[3
]}

Hovav, Avi-Hai ^{[4
]}

Henke, Erik ^{[5
]}

Fridlender, Zvi G. ^{[2
]}

Granot, Zvi ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Sch Med, Inst Med Res Israel Canada, Dept Dev Biol & Canc Res, IL-91120 Jerusalem, Israel

[2] Hadassah Hebrew Univ Med Ctr, Inst Pulm Med, IL-91120 Jerusalem, Israel

[3] Univ Haifa, Fac Nat Sci, Dept Biol, IL-31905 Haifa, Israel

[4] Hebrew Univ Jerusalem, Hadassah Sch Dent Med, Inst Dent Sci, IL-91120 Jerusalem, Israel

[5] Univ Wurzburg, Inst Anat & Cell Biol Tumour Angiogenesis & Expt, D-97070 Wurzburg, Germany

来源：

CELL REPORTS | 2015年 / 10卷 / 04期

关键词：

SUPPRESSOR-CELLS; INNATE IMMUNITY; TUMOR; ADENOCARCINOMA; INHIBITION; BETA; MACROPHAGES; METASTASIS; SUBSETS; GROWTH;

D O I：

10.1016/j.celrep.2014.12.039

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Controversy surrounds neutrophil function in cancer because neutrophils were shown to provide both pro-and antitumor functions. We identified a heterogeneous subset of low-density neutrophils (LDNs) that appear transiently in self-resolving inflammation but accumulate continuously with cancer progression. LDNs display impaired neutrophil function and immunosuppressive properties, characteristics that are in stark contrast to those of mature, high-density neutrophils (HDNs). LDNs consist of both immature myeloid-derived suppressor cells (MDSCs) and mature cells that are derived from HDNs in a TGF-beta-dependent mechanism. Our findings identify three distinct populations of circulating neutrophils and challenge the concept that mature neutrophils have limited plasticity. Furthermore, our findings provide a mechanistic explanation to mitigate the controversy surrounding neutrophil function in cancer.

引用

页码：562 / 573

页数：12

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