Biomedical applications of chitosan electrospun nanofibers as a green polymer - Review

被引:283
|
作者
Kalantari, Katayoon [1 ]
Afifi, Amalina M. [1 ]
Jahangirian, Hossein [2 ]
Webster, Thomas J. [2 ]
机构
[1] Univ Malaya, Fac Engn, Dept Mech Engn, CAM, Kuala Lumpur 50603, Malaysia
[2] Northeastern Univ, Snell Engn Ctr 313, Dept Chem Engn, 360 Huntington Ave, Boston, MA 02115 USA
关键词
Chitosan; Nanofibers; Electrospinning; Biomedical applications; Tissue engineering; IN-VITRO; DELIVERY-SYSTEM; TETRACYCLINE HYDROCHLORIDE; ANTIMICROBIAL PROPERTIES; COMPOSITE NANOFIBERS; SUSTAINED DELIVERY; CONTROLLED-RELEASE; DRUG-DELIVERY; SCAFFOLDS; MATS;
D O I
10.1016/j.carbpol.2018.12.011
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
This review outlines new developments in the biomedical applications of environmentally friendly ('green') chitosan and chitosan-blend electrospun nanofibers. In recent years, research in functionalized nanofibers has contributed to the development of new drug delivery systems and improved scaffolds for regenerative medicine, which is currently one of the most rapidly growing fields in all of the life sciences. Chitosan is a biopolymer with non-toxic, antibacterial, biodegradable and biocompatible properties. Due to these properties, they are widely applied for biomedical applications such as drug delivery, tissue engineering scaffolds, wound dressings, and antibacterial coatings. Electrospinning is a novel technique for chitosan nanofiber fabrication. These nanofibers can be used in unique applications in biomedical fields due to their high surface area and porosity. The present work reviews recent reports on the biomedical applications of chitosan-based nanofibers in detail.
引用
收藏
页码:588 / 600
页数:13
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